Detailed information of TA system TA164734

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3578451..3579285
• Replicon: chromosome
• Accession: NZ_CP057093
• Organism: Escherichia fergusonii strain RHB38-C07

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2X7CAN1
• Locus tag: HVZ69_RS17515
• Protein ID: WP_039025883.1
• Coordinates: 3578451..3578828 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2X5LBZ2
• Locus tag: HVZ69_RS17520
• Protein ID: WP_039025882.1
• Coordinates: 3578917..3579285 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ69_RS17480	3574212..3574523	+	312	Protein_3408	hypothetical protein	-
HVZ69_RS17485	3574659..3574760	+	102	WP_000662204.1	hypothetical protein	-
HVZ69_RS17490	3574901..3575166	+	266	Protein_3410	tyrosine-type recombinase/integrase	-
HVZ69_RS17495	3575392..3576711	+	1320	WP_105284452.1	site-specific integrase	-
HVZ69_RS17500	3576804..3577652	-	849	WP_039025884.1	DUF4942 domain-containing protein	-
HVZ69_RS17505	3577749..3577946	-	198	WP_000772024.1	DUF957 domain-containing protein	-
HVZ69_RS17510	3577966..3578454	-	489	Protein_3414	hypothetical protein	-
HVZ69_RS17515	3578451..3578828	-	378	WP_039025883.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HVZ69_RS17520	3578917..3579285	-	369	WP_039025882.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HVZ69_RS17525	3579335..3579979	-	645	WP_039025881.1	hypothetical protein	-
HVZ69_RS17530	3579994..3580215	-	222	WP_000692312.1	DUF987 domain-containing protein	-
HVZ69_RS17535	3580284..3580760	-	477	WP_001186745.1	RadC family protein	-
HVZ69_RS17540	3580775..3581260	-	486	WP_000214316.1	antirestriction protein	-
HVZ69_RS17545	3581351..3582169	-	819	WP_001234702.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14176.22 Da
• Isoelectric Point: 7.8523

>T164734 WP_039025883.1 NZ_CP057093:c3578828-3578451 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Nucleotide

• Length: 378 bp

>T164734 NZ_CP073236:c4409832-4409506 [Klebsiella pasteurii]
ATGAAAATCCTTTCTGAAAATCAGCGGGGAGCGAAGCCATGCCCGCCGCCTGTGCTTGTCTGGCAAACGCTGCTTACACG
TCTGCTGGAGCAACACTATGGCCTGACGCTGAACGACACGCCATTCAGTGATGAAACTGTTATTCAGGAGCATATCGACG
CCGGTATCACGCTGGCGGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTTAAC
TGTCAGGAGCAGTCACCTTATCTTCGGGCGGTAGATATTTTACGGGCGCGGCAGGCAACTGGGTTATTGAAACGCAATCG
GAGGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13792.52 Da
• Isoelectric Point: 5.9582

>AT164734 WP_039025882.1 NZ_CP057093:c3579285-3578917 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT164734 NZ_CP073236:c4410183-4409857 [Klebsiella pasteurii]
ATGGAAAAACACGATAACCCTGAATGGGGACTTCGTTGTGATGTAATGCCTCGCTTTAGTGCAAGGCTGGTACAGGAAGG
CAACCGCCTGCATTATTTAGCTGACCGCGCCGGGATAACTGGCGCTTTCGAAGAAGAAGAGTGTCACCAACTAAATAGCG
CATTTCCGCACTTTACAGAGCAGATGGAATTGATGCTGCTTTCTGGTGAGCTTAACCCCCGCCATGCACACCGTGTCACT
CTGTACCATGACGAACTGACCTGTGAAGCGGATACGCTCGGTTCGCACGGCTACGTTTATATCGCTATCTATCCCACTCA
ACGCTAA

Structures

Toxin

• AlphaFold DB: A0A2X7CAN1

Antitoxin

• AlphaFold DB: A0A2X5LBZ2