Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3454272..3454891 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVZ69_RS16910 Protein ID WP_001280991.1
Coordinates 3454673..3454891 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVZ69_RS16905 Protein ID WP_000344803.1
Coordinates 3454272..3454646 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS16895 3449404..3450597 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ69_RS16900 3450620..3453769 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVZ69_RS16905 3454272..3454646 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVZ69_RS16910 3454673..3454891 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVZ69_RS16915 3455388..3455858 + 471 WP_002431406.1 YlaC family protein -
HVZ69_RS16920 3455997..3457547 + 1551 WP_181587816.1 EAL domain-containing protein -
HVZ69_RS16925 3457589..3457942 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVZ69_RS16935 3458321..3458632 + 312 WP_000409911.1 MGMT family protein -
HVZ69_RS16940 3458663..3459235 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T164733 WP_001280991.1 NZ_CP057093:3454673-3454891 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T164733 NZ_CP073236:c3029043-3028633 [Klebsiella pasteurii]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGCGCGCAGTGGTTCTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTATTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATATTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCCGTCAGGGTGAAATAAAGCTGCTGATCGACTCGCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGTCGGCTAGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT164733 WP_000344803.1 NZ_CP057093:3454272-3454646 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164733 NZ_CP073236:c3029290-3029024 [Klebsiella pasteurii]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References