Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 800400..800950 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HVZ69_RS04000 Protein ID WP_001160963.1
Coordinates 800636..800950 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HVZ69_RS03995 Protein ID WP_000125566.1
Coordinates 800400..800633 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS03970 795472..795759 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HVZ69_RS03975 795818..797149 + 1332 WP_181588354.1 MFS transporter -
HVZ69_RS03980 797257..797787 + 531 WP_000600726.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HVZ69_RS03985 797780..799642 + 1863 WP_181588355.1 glutathione-regulated potassium-efflux system protein KefC -
HVZ69_RS03990 799835..800314 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HVZ69_RS03995 800400..800633 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVZ69_RS04000 800636..800950 + 315 WP_001160963.1 CcdB family protein Toxin
HVZ69_RS04005 800947..801795 - 849 WP_088541456.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HVZ69_RS04010 801802..802179 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HVZ69_RS04015 802182..803003 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HVZ69_RS04020 803000..803989 - 990 WP_000241252.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HVZ69_RS04025 803989..805275 - 1287 WP_000800490.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T164720 WP_001160963.1 NZ_CP057093:800636-800950 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T164720 NZ_CP073111:388204-388497 [Agrobacterium rhizogenes]
ATGCGTTTTAGCCTTTTTGTCGAAGCGGAAGAGGACATTATTGCGATCGCCGAGCAAGGCGTCCGCTTGTTCGGATCCGT
ACAGGCTAGGCGATATCATGACGAACTATTCTCGCTGCTTGACCTGATTGCCGCTAATCCACGAATGGCGCGTGAGCGAG
AAGAGATTTCGCCGCCGGTCAGAATCCACCCGTTCAAAGCCCATCTCGTTGTCTATCGGATCGAAGAAGACGGAGCCATT
TTCGTGATCCGAATACGTCATGGACATGAAGACTGGGCGAGCGATTCTGTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT164720 WP_000125566.1 NZ_CP057093:800400-800633 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT164720 NZ_CP073111:387950-388204 [Agrobacterium rhizogenes]
ATGGCTACGATGAACGTGTCTTTGCCGGACCCAATGAAAGATTGGGTCGAGGCGCAAGCCAAGACCGGGCGATATTCCAA
CGCCAGTGACTATGTGCGCGACCTGATTCGAAGGGACCAAGTGCGCAGTGATAAGATTGCCGCCATGCAACGCTTCGTCG
ATGACGGTCTCAAAAGTGGTGTTGGTGGCCGGTCGAAGGACGAACTCTTTGCCACGGCAATCGCACATGGGGAGATGACG
CGCGGCGACAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References