Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 338085..339073 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag HVZ69_RS01595 Protein ID WP_014640052.1
Coordinates 338687..339073 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0J5Z6D5
Locus tag HVZ69_RS01590 Protein ID WP_000458584.1
Coordinates 338085..338657 (+) Length 191 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS01565 334213..334581 + 369 WP_181588230.1 diacylglycerol kinase -
HVZ69_RS01570 334691..335299 + 609 WP_000646099.1 transcriptional repressor LexA -
HVZ69_RS01575 335372..336697 + 1326 WP_181598218.1 MATE family efflux transporter DinF -
HVZ69_RS01580 336829..337038 + 210 WP_001030605.1 CsbD family protein -
HVZ69_RS01585 337089..337604 - 516 WP_181588232.1 zinc uptake transcriptional repressor Zur -
HVZ69_RS01590 338085..338657 + 573 WP_000458584.1 SocA family protein Antitoxin
HVZ69_RS01595 338687..339073 + 387 WP_014640052.1 hypothetical protein Toxin
HVZ69_RS01600 339113..339286 + 174 WP_000390072.1 hypothetical protein -
HVZ69_RS01605 339334..339615 - 282 WP_001093917.1 pyocin activator PrtN family protein -
HVZ69_RS01610 339652..340224 - 573 WP_001061348.1 3'-5' exoribonuclease -
HVZ69_RS01615 340224..341033 - 810 WP_000206745.1 hypothetical protein -
HVZ69_RS01620 341033..341395 - 363 WP_001242749.1 phage protein -
HVZ69_RS01625 341386..341922 - 537 WP_062858077.1 5'-deoxynucleotidase -
HVZ69_RS01630 342050..342874 - 825 WP_001569327.1 DUF2303 family protein -
HVZ69_RS01635 342940..343302 - 363 WP_000135680.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(27-137)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T164716 WP_014640052.1 NZ_CP057093:338687-339073 [Escherichia fergusonii]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T164716 NZ_CP073110:c2959240-2958374 [Agrobacterium rhizogenes]
ATGGCTAAAGAGATCAAGAACATCGGCGCCTCGGTGCGCGCACGTCTGCTGCAACTCGCCAAGGCAAGTGGCCAGAGCTT
CGACCTGGTTCTGACCCGCTTCGCCCTCGAGCGGCTGCTCTTCCGGCTCAGCCGGTCAAGCCATGCCGACCGTTTCGTGC
TGAAGGGCGCCATGTTGATGATGAGTTGGTTCGACGACCCACACCGCGGCACGCGCGACCTTGATCTGCTGGGTTTCGGT
GATCCGAGTGCGGAGCTAATGCTGGCGACGTTTCGGGAGATCCTGGCGCAGGACGCCAGCGATGGCGTCGAGTTCGACGC
TGACGCACTTCGCGTCGACCGCATTCGCGAAGAGCTGGAATATGGCGGGCTGAGGCTGAGGACGACAGCTTCGATCAGCG
GCGCCCGGATCAGCCTGACGATCGACATCGGCTTTGGCGATGCGCTGGAGCCTGGCACCGAGGAGCTGGACTATCCTTCG
ATGCTGGACTTTCCCATGCCCCGGCTGCGGGGCTACGCCCGGGAGACTGTCATTGCCGAGAAATTCCAGGCGATGGTGGC
GCTGGGGCGTGCCAACACTCGGATGAAAGATTTCTACGACATCTGGATTCTCAGCAGGTCGTTCGATTTCAGCAATGACA
GGTTGGTGCGGGCAATTACCGGCACTTTCGAACGGCGTGAGACGCCGATCCCAACGGTGCTACCGGATGCTTTAACGGAA
GCATTTGCCCAGGATCAGCAAAAGCAACGGCAATGGCGAGCGTTTGTTGAAGACGTTGCCCATAACCCGGGTGAATTGAT
GGATGTCATCACGGATATCGCCGGATTCCTGATGCCTCATGCCGCAGCCGCGAGCCGGGGCAAATGA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21973.21 Da        Isoelectric Point: 6.0283

>AT164716 WP_000458584.1 NZ_CP057093:338085-338657 [Escherichia fergusonii]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT164716 NZ_CP073110:c2959850-2959233 [Agrobacterium rhizogenes]
ATGCCCGAATCTATCTCCCAGCGCCAAATCGCCCACGCCCTCCTGACGGCGCGTGGGATCGCGCGTCTTGTAGAGCTGCG
CGATGCTGGCGTAACGGCCGCAACGATGAGCCGCATGGAGCGGGATGGGGAGGTGCTCCGGCTTGCACGGGGCCTTTATC
AGCTCTCCGACGCGCCGCTCGACGCCAACCACAGTCTGGCCGAGGCCGCTAAACGCCTACCCAAGGGTGTTGTCTGCCTT
GTGTCGGCCCTCGCGTTCCACGGCCTGACCGACCAGCTTCCGAAGCAGGTGTGGCTGGCGATAGGGCGGAAGGATTGGGC
TCCCAAACCCGACAGTACGCCTATTCGGATCGTGCGCTTCACCGACAGACTGCTCAATGAAAGCGTAGAGACCCATGTCG
TCGAAGGTGTGCCCGTAAAGGTCTTTGGGATCGTCAAAACAATCGCGGACTGTTTCCGATATCGCAACAAGATCGGTCTG
TCGGTGGCGATCGAGGGCCTCCAAGAAGTGCTCCGTCAGCGTAAGGCCACCCCCGGTGAAATTGCCAGGCAGGCCGAGCG
TGGCGGTGTCGCCACGGTCATCCGGCCGTATATCGAGGCGCTGACTGCCAATGGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0J5Z6D5

References