Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4142659..4143278 Replicon chromosome
Accession NZ_CP057069
Organism Klebsiella pneumoniae strain RHB39-C09

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVZ81_RS20385 Protein ID WP_002892050.1
Coordinates 4143060..4143278 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HVZ81_RS20380 Protein ID WP_002892066.1
Coordinates 4142659..4143033 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ81_RS20370 4137811..4139004 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ81_RS20375 4139027..4142173 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HVZ81_RS20380 4142659..4143033 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HVZ81_RS20385 4143060..4143278 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVZ81_RS20390 4143437..4144003 + 567 WP_002892030.1 maltose O-acetyltransferase -
HVZ81_RS20395 4143975..4144115 - 141 WP_004147370.1 hypothetical protein -
HVZ81_RS20400 4144136..4144606 + 471 WP_002892026.1 YlaC family protein -
HVZ81_RS20405 4144581..4146032 - 1452 WP_004177237.1 PLP-dependent aminotransferase family protein -
HVZ81_RS20410 4146133..4146831 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
HVZ81_RS20415 4146828..4146968 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HVZ81_RS20420 4146968..4147231 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T164712 WP_002892050.1 NZ_CP057069:4143060-4143278 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T164712 NZ_CP073101:836354-836620 [Exiguobacterium alkaliphilum]
ATGAGTAAATCTTTATTATTCACTGACAATGGGTGGGAAGATTATTTGTATTGGCAAAAAGAAGATAAAAAGAAATTAAA
GCGAATCAATTTGTTAATCGAGGATGTTAGAAGAAACGGAAACTTAAATGGGATAGGTAAACCAGAAGCATTAAAAGGGA
ACTTACAAGGTTTCTATAGTCGTAGAATTGATTCAGAGCACAGACTCGTTTATAGAGTTATGAATCAATATGTAGAGATT
TTACAATGTCGTTATCACTACTTGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT164712 WP_002892066.1 NZ_CP057069:4142659-4143033 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT164712 NZ_CP073101:836107-836361 [Exiguobacterium alkaliphilum]
ATGTCTACAATTACCTACAGTGATGCACGTAAAAACTTTAAAAAAGTATTAGATCAAGTCCATGAAAATAGCGAAGCGAT
TGTCATCTCACGAAAGAATAGTGAAAATGCGGTCATTATGTCGGAGCAAGAATACGAGAGCTTAATGGAAACCATTTATT
TGTTGAGAAGCCCGAAAAATGCGGAGCGGCTATTAGAATCTATTAAACAGATTGAAAATAATGAGGTCACAGAAAGAGAA
TTAATGAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References