Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822116..822773 Replicon chromosome
Accession NZ_CP057069
Organism Klebsiella pneumoniae strain RHB39-C09

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HVZ81_RS04130 Protein ID WP_002916310.1
Coordinates 822363..822773 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HVZ81_RS04125 Protein ID WP_002916312.1
Coordinates 822116..822382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ81_RS04100 817272..818705 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HVZ81_RS04105 818824..819552 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HVZ81_RS04110 819602..819913 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HVZ81_RS04115 820077..820736 + 660 WP_002916317.1 hemolysin III family protein -
HVZ81_RS04120 820887..821870 - 984 WP_181590303.1 tRNA-modifying protein YgfZ -
HVZ81_RS04125 822116..822382 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HVZ81_RS04130 822363..822773 + 411 WP_002916310.1 protein YgfX Toxin
HVZ81_RS04135 822780..823301 - 522 WP_181590304.1 flavodoxin FldB -
HVZ81_RS04140 823402..824298 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HVZ81_RS04145 824321..825034 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ81_RS04150 825040..826773 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164701 WP_002916310.1 NZ_CP057069:822363-822773 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164701 NZ_CP073082:c142295-142014 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164701 WP_002916312.1 NZ_CP057069:822116-822382 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164701 NZ_CP073082:c142519-142292 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References