Detailed information of TA system TA164692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/GNAT-DUF1778
• Location: 112474..113225
• Replicon: plasmid pRHB39-C10_2
• Accession: NZ_CP057067
• Organism: Klebsiella pneumoniae strain RHB39-C10

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A8T3UHS1
• Locus tag: HVZ82_RS25630
• Protein ID: WP_004883482.1
• Coordinates: 112474..112956 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A8T3UKU4
• Locus tag: HVZ82_RS25635
• Protein ID: WP_004883484.1
• Coordinates: 112947..113225 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ82_RS25615	108300..110033	+	1734	WP_181591801.1	protein phosphatase 2C domain-containing protein	-
HVZ82_RS25620	110061..111560	+	1500	WP_086528915.1	kinase	-
HVZ82_RS25625	111939..112421	+	483	WP_004196929.1	hypothetical protein	-
HVZ82_RS25630	112474..112956	-	483	WP_004883482.1	GNAT family N-acetyltransferase	Toxin
HVZ82_RS25635	112947..113225	-	279	WP_004883484.1	DUF1778 domain-containing protein	Antitoxin
HVZ82_RS25640	114031..114267	-	237	WP_077251651.1	bacteriocin immunity protein	-
HVZ82_RS25645	114360..115193	-	834	WP_004883492.1	GIY-YIG nuclease family protein	-
HVZ82_RS25650	115528..115932	-	405	WP_086528925.1	DUF2251 domain-containing protein	-
HVZ82_RS25655	116108..118069	-	1962	WP_112029085.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..242087	242087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (69-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-86)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17491.36 Da
• Isoelectric Point: 9.4950

>T164692 WP_004883482.1 NZ_CP057067:c112956-112474 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVINEWLKKKALRNHGTGISRVFVVCSENSKRVIAYYCLSSGSVHRNTVTGTYRRNAP
AAIPVIVLGRLAVDAAWAGKGIGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVVAFYTKFGFETSAVNALTLLFPVKV

Nucleotide

• Length: 483 bp

>T164692 NZ_CP073080:4098325-4098903 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGTGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10720.23 Da
• Isoelectric Point: 4.5423

>AT164692 WP_004883484.1 NZ_CP057067:c113225-112947 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFLLDDKQFDTFIEELDAPVTPERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT164692 NZ_CP073080:4097683-4098237 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA