Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795714..796371 Replicon chromosome
Accession NZ_CP057066
Organism Klebsiella pneumoniae strain RHB39-C10

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HVZ82_RS03965 Protein ID WP_002916310.1
Coordinates 795961..796371 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HVZ82_RS03960 Protein ID WP_002916312.1
Coordinates 795714..795980 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ82_RS03935 790870..792303 - 1434 WP_065801036.1 6-phospho-beta-glucosidase -
HVZ82_RS03940 792422..793150 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HVZ82_RS03945 793200..793511 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HVZ82_RS03950 793675..794334 + 660 WP_002916317.1 hemolysin III family protein -
HVZ82_RS03955 794485..795468 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HVZ82_RS03960 795714..795980 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HVZ82_RS03965 795961..796371 + 411 WP_002916310.1 protein YgfX Toxin
HVZ82_RS03970 796378..796899 - 522 WP_002916308.1 flavodoxin FldB -
HVZ82_RS03975 797000..797896 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HVZ82_RS03980 797919..798632 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ82_RS03985 798638..800371 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164675 WP_002916310.1 NZ_CP057066:795961-796371 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164675 NZ_CP073061:67182-67349 [Acinetobacter baumannii]
TTGCGCTTAAAATCTCAAGAATGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCATAG
TTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGCGA
ACACATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164675 WP_002916312.1 NZ_CP057066:795714-795980 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164675 NZ_CP073061:67336-67623 [Acinetobacter baumannii]
ATGCGAACACATGAAGAAATGAAAGCACTAGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCTTGCTCGATATGGTACTTACTGCACTTCGAGAGGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAATGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References