Detailed information of TA system TA164670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 87263..87906
• Replicon: plasmid pRHB39-C24_2
• Accession: NZ_CP057035
• Organism: Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: HVZ90_RS25730
• Protein ID: WP_014386165.1
• Coordinates: 87263..87679 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: HVZ90_RS25735
• Protein ID: WP_032408893.1
• Coordinates: 87676..87906 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ90_RS25715	83412..85445	+	2034	WP_042944097.1	alpha-amylase	-
HVZ90_RS25720	85617..86141	+	525	Protein_93	valine--pyruvate transaminase	-
HVZ90_RS25725	86198..87166	-	969	WP_181578648.1	IS5 family transposase	-
HVZ90_RS25730	87263..87679	-	417	WP_014386165.1	PIN domain-containing protein	Toxin
HVZ90_RS25735	87676..87906	-	231	WP_032408893.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HVZ90_RS25740	88226..88660	+	435	WP_000103648.1	RidA family protein	-
HVZ90_RS25745	88665..89339	+	675	WP_000175734.1	DUF1028 domain-containing protein	-
HVZ90_RS25750	89355..90512	+	1158	WP_038807146.1	acetylornithine deacetylase	-
HVZ90_RS25755	90683..91831	+	1149	WP_075253165.1	ABC transporter ATP-binding protein	-
HVZ90_RS25760	91838..92833	+	996	WP_000611945.1	NAD(P)H-quinone oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..227199	227199

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15127.44 Da
• Isoelectric Point: 7.8841

>T164670 WP_014386165.1 NZ_CP057035:c87679-87263 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Nucleotide

• Length: 417 bp

>T164670 NZ_CP073061:c56806-56525 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAACAATTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8854.89 Da
• Isoelectric Point: 4.5112

>AT164670 WP_032408893.1 NZ_CP057035:c87906-87676 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Nucleotide

• Length: 231 bp

>AT164670 NZ_CP073061:c57109-56807 [Acinetobacter baumannii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA