Detailed information of TA system TA164668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 32166..33076
• Replicon: plasmid pRHB39-C24_2
• Accession: NZ_CP057035
• Organism: Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)

• Gene name: -
• Uniprot ID: R4YBC5
• Locus tag: HVZ90_RS25420
• Protein ID: WP_004144067.1
• Coordinates: 32606..33076 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HVZ90_RS25415
• Protein ID: WP_023288274.1
• Coordinates: 32166..32609 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ90_RS25385	27332..28138	-	807	Protein_26	IS5 family transposase	-
HVZ90_RS25390	28741..29289	+	549	WP_023320124.1	GNAT family N-acetyltransferase	-
HVZ90_RS25395	29412..30380	-	969	WP_181578646.1	IS5 family transposase	-
HVZ90_RS25400	30413..31249	-	837	Protein_29	IS5 family transposase	-
HVZ90_RS25405	31269..31454	+	186	WP_071953846.1	DUF2188 domain-containing protein	-
HVZ90_RS25410	31554..32066	+	513	Protein_31	DUF4113 domain-containing protein	-
HVZ90_RS25415	32166..32609	+	444	WP_023288274.1	DUF2384 domain-containing protein	Antitoxin
HVZ90_RS25420	32606..33076	+	471	WP_004144067.1	RES family NAD+ phosphorylase	Toxin
HVZ90_RS25425	33186..33446	-	261	WP_149358982.1	hypothetical protein	-
HVZ90_RS25430	34018..34464	-	447	Protein_35	transposase	-
HVZ90_RS25435	34523..35491	-	969	WP_000654804.1	IS5-like element IS903B family transposase	-
HVZ90_RS25440	35859..36647	-	789	WP_023288270.1	arylamine N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..227199	227199
	-	inside	IScluster/Tn	-	-	26309..49418	23109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17573.83 Da
• Isoelectric Point: 4.5152

>T164668 WP_004144067.1 NZ_CP057035:32606-33076 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T164668 NZ_CP073060:c356223-355822 [Acinetobacter baumannii]
ATGTTGAGATATATGTTAGATACCAATATCGTGATCTATACCATCAAAAATAAACCGCCTGAAGTTAAAGTGCGATTTAA
TGCTGTTGCCACTCAGTTATGTGTCAGTAGTATCACTGTGGCAGAACTTATTTATGGTGCAGAAAATAGTCAAAACCCTA
TAAAAAATTTACGCGTTGTCGAAGATTTTTTATCTCGATTACAGATTTTAGATTATACCCCTGAAGCAGCAGCTCAATAT
GGCATGATCAAAGCAGATTTACGTCGTAAAGGCACGCTTATTAGTGATAATGACACGCATATTGCAGCTCATGCTCGTAG
TCATGGTCTTATTTTAGTTACTAACAATACTAAAGAATTTCAAAGAGTCGAAGCTTTGCAGTTAGAGAATTGGGTTGAGT
GA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16536.87 Da
• Isoelectric Point: 10.3013

>AT164668 WP_023288274.1 NZ_CP057035:32166-32609 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRVVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT164668 NZ_CP073060:c356450-356223 [Acinetobacter baumannii]
ATGATTACATCTGTATTTACAAATAATCGCTCCCAAGCTGTTCGCTTACCAGCTATTTTTCGCTTTCCTAAAGAAACACA
AAAAGTCTTTGTAAGGGTCGTTGGTGTAGAACGCGTCATTTGCCCTGTGGAACATATTTGGGACAGTTTTTTTGATGATG
CTCAACTCACCGTTTCAGATGATTTTGAGCGTGGTGAACAAATTGCAGCGGAGCGTGAGAGTTTTTGA

Structures

Toxin

• AlphaFold DB: A0A384IED8