Detailed information of TA system TA164666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4782923..4784604
• Replicon: chromosome
• Accession: NZ_CP057034
• Organism: Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A483YLF8
• Locus tag: HVZ90_RS23385
• Protein ID: WP_019724882.1
• Coordinates: 4782923..4783840 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HVZ90_RS23390
• Protein ID: WP_004177809.1
• Coordinates: 4783846..4784604 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ90_RS23365	4778229..4779749	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HVZ90_RS23370	4779746..4780744	+	999	WP_002885172.1	ribose ABC transporter permease	-
HVZ90_RS23375	4780775..4781716	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HVZ90_RS23380	4781791..4782798	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
HVZ90_RS23385	4782923..4783840	-	918	WP_019724882.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HVZ90_RS23390	4783846..4784604	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HVZ90_RS23395	4784690..4785418	-	729	WP_002885152.1	response regulator transcription factor	-
HVZ90_RS23400	4785691..4787838	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
HVZ90_RS23405	4788068..4788754	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34653.14 Da
• Isoelectric Point: 5.4707

>T164666 WP_019724882.1 NZ_CP057034:c4783840-4782923 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T164666 NZ_CP073020:c36479-36189 [Synechocystis sp. PCC 6803]
ATGATTGAAATCCGGCAAACAGAAACCTATGCCCGTTGGTTTAAGTCTTTGCGGGATTGCCAGGCAAAAGCCCGAATTGA
TATTCGTATTCGCCGTCTATCCTTGGTTAATGCTGGGGACGTTAAGTCGGTAGGGGGTGGGGTTTCAGAACTTCGGATTA
ACTACGGCCCCGGCTATCGCATCTATTTCACCCAGCAGGGAGAACAGTTAATTATTTTGTTGGCTGGCGGCGACAAGCAG
ACCCAATCCAATGACATCACCATTGCCCGTGATTTAGCCAAAGAACTATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT164666 WP_004177809.1 NZ_CP057034:c4784604-4783846 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT164666 NZ_CP073020:c36178-35891 [Synechocystis sp. PCC 6803]
ATGGAAACCCTTAAAACTATCCCTTGGGATGCCGCCGATCACCTAGAAAGCCGTGAAGACATGGCCGCTTATCTCGAAGC
CGCCCTTGAAGAAGGAGACCCTGCTCTAATCCTCGTAGCGCTGGGAGACATAGCCCGTTCCAAAGGGATGACACTGATTG
CAAAGGAAACAGGATTGGGACGGGAAAGCCTCTATAAAGCCCTATCTGCCAATGGAAATCCTGAATTTGTAACGGTTTTG
AAAGTCATGGAAGCCCTAGGACTACGCCTCCAAGCCACGACACTCTAA

Structures

Toxin

• AlphaFold DB: A0A483YLF8

Antitoxin

• AlphaFold DB: A6TH05