Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3904851..3905470 Replicon chromosome
Accession NZ_CP057034
Organism Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVZ90_RS19185 Protein ID WP_002892050.1
Coordinates 3905252..3905470 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HVZ90_RS19180 Protein ID WP_002892066.1
Coordinates 3904851..3905225 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ90_RS19170 3900003..3901196 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ90_RS19175 3901219..3904365 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HVZ90_RS19180 3904851..3905225 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HVZ90_RS19185 3905252..3905470 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVZ90_RS19190 3905629..3906195 + 567 WP_002892030.1 maltose O-acetyltransferase -
HVZ90_RS19195 3906167..3906307 - 141 WP_004147370.1 hypothetical protein -
HVZ90_RS19200 3906328..3906798 + 471 WP_002892026.1 YlaC family protein -
HVZ90_RS19205 3906773..3908224 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HVZ90_RS19210 3908325..3909023 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
HVZ90_RS19215 3909020..3909160 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HVZ90_RS19220 3909160..3909423 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T164663 WP_002892050.1 NZ_CP057034:3905252-3905470 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T164663 NZ_CP073017:3347085-3347447 [Synechocystis sp. PCC 6803]
ATGTCGAATAATCTCCATTTAGTCAATATCGACTTCACCCCCGAATATAGGAGAAGTTTAAAATATTTAGCCAAGAAATA
TCGAAATATTCGTTCTGATGTTCAGCCCATTATTGAGGCTTTGCAAAAAGGCGTCATTAGTGGTGATCGCCTGGCAGGGT
TTGGCTCTGATATTTACGTCTATAAGCTTAGAATTAAGAATAGTAATATTCAGAAAGGGAAAAGTTCTGGCTACCGATTA
ATTTATTTACTCGAATCAGAAAACAGTATTTTGTTGTTAACCATTTACAGTAAAGCTGAACAAGAAGATATTGCCGCTAG
TGACATTAATTCAATTTTAGGGGAGTACTCCATAGAAGACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT164663 WP_002892066.1 NZ_CP057034:3904851-3905225 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT164663 NZ_CP073017:3346835-3347095 [Synechocystis sp. PCC 6803]
ATGATGAGAGCTTTTGAGGTAATGGCCACAGTTAAAGATTCCAAACAATTGCTCTTGGATAGTGATTTGCATTGGAATAC
CAGCCGAGTCAAGGTGATTATTTTGGAATCAGATGAATTGGCATCAAAAGGAAGTGAGTTTGATCCTGATGACACGCCTG
TCGAAGAAATTAAGGTGAGTTTGAGGAAGGCATTAGAGGAATATAAACAAGGAAAAAGAATTCCAGTAGAAAATATGTGG
GAGGGAATTGATGTCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References