Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2606908..2608496 Replicon chromosome
Accession NZ_CP057034
Organism Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag HVZ90_RS12870 Protein ID WP_016946382.1
Coordinates 2606908..2608230 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HVZ90_RS12875 Protein ID WP_002904790.1
Coordinates 2608230..2608496 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ90_RS12855 2601964..2604465 + 2502 WP_023282574.1 fimbrial biogenesis outer membrane usher protein -
HVZ90_RS12860 2604453..2605457 + 1005 WP_016946380.1 type 1 fimbrial protein -
HVZ90_RS12865 2605599..2606891 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
HVZ90_RS12870 2606908..2608230 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
HVZ90_RS12875 2608230..2608496 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HVZ90_RS12880 2608883..2609209 - 327 WP_004215084.1 hydroxyisourate hydrolase -
HVZ90_RS12885 2609206..2609706 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HVZ90_RS12890 2609684..2611063 - 1380 WP_004184021.1 purine permease -
HVZ90_RS12895 2611409..2612563 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
HVZ90_RS12900 2612544..2613467 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T164662 WP_016946382.1 NZ_CP057034:c2608230-2606908 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T164662 NZ_CP073017:c3261353-3260958 [Synechocystis sp. PCC 6803]
GTGAAACTTTTGTTGGATACCCAGTGCTGGTTATGGTGGTTTACTGAGCCGGAAAAATTGAACGAAGATGCAATTTCCCA
GATCATAGATGAGACAAACGAAATATGGCTTTCTGTTGCCAGTATTTGGGAAATGTCAATTAAGACTTCCATCGGTAAAC
TGCCCTTGCCAGAAAATATTGACGACTACATTCTCAGTCGCATGGTGAAATTGGGTGCTGAGTTCCTGGACATTAAAACC
CGCCATGCCCTGCAAGTTGCGACATTGCCCCTACATCACCGTGATCCGTTTGACAGAATTATCATTGCCCAGGCACAAAC
AGAAAATATGCTGCTAATTAGTGCAGATTCAATGTTTAAAAATTATGGAGTCTCTTTGTTATGGGCGGGAGTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT164662 WP_002904790.1 NZ_CP057034:c2608496-2608230 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT164662 NZ_CP073017:c3261643-3261365 [Synechocystis sp. PCC 6803]
ATGATCGGAGTTAGCGTTAATCCAGAGAAACTAGGATCCACTATGGAGACCGTCAATGTTGACCAAATAGAAATCAATCT
TCCTGAGCTTTTGTACAGTATCAAACCAGGGGAAGAAGTCATCGTTGCTGACCAGGGTATTCCCATTGCTAAGTTGGTTC
CTCTGCAAAGGCAAAAATCCGTGGATCGATGCTCCAGCTTAGGGGTAGATCGAGGATTATTTGTAGTGCCAGATGACTTT
AACGATCCTTTACCAAATGATATTTGGCCATTATCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References