Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 793674..794331 Replicon chromosome
Accession NZ_CP057034
Organism Klebsiella pneumoniae strain RHB39-C24

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HVZ90_RS03955 Protein ID WP_002916310.1
Coordinates 793921..794331 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HVZ90_RS03950 Protein ID WP_002916312.1
Coordinates 793674..793940 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ90_RS03925 788830..790263 - 1434 WP_181578605.1 6-phospho-beta-glucosidase BglA -
HVZ90_RS03930 790382..791110 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HVZ90_RS03935 791160..791471 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HVZ90_RS03940 791635..792294 + 660 WP_002916317.1 hemolysin III family protein -
HVZ90_RS03945 792445..793428 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HVZ90_RS03950 793674..793940 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HVZ90_RS03955 793921..794331 + 411 WP_002916310.1 protein YgfX Toxin
HVZ90_RS03960 794338..794859 - 522 WP_004144730.1 flavodoxin FldB -
HVZ90_RS03965 794960..795856 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HVZ90_RS03970 795879..796592 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ90_RS03975 796598..798331 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164653 WP_002916310.1 NZ_CP057034:793921-794331 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164653 NZ_CP073013:c3063306-3062938 [Marinomonas profundi]
ATGATTTGGGAGATATTAATAACTGACGAGTACGAGCAATGGTTTCTTGGCTTGACGGACAAAGAGCAAGAAGACGTGCT
TTCAATGGTTGATGTATTAGAAATCAAAGGTCCTCTATTAGCTAGGCCATATGCTGATTCACTAAAAGGAACAGACAAGG
TAAAAAACCTTAAAGAGTTGAGAATTCAGCATGCAGGAAAACCTTATCGTGTCTTTTATGCTTTTGACCCAAAAAGGAAA
GTCATCTTGTTATGTGGTGGCCGCAAAAATGGGAAAAGAAATAAAACATTTTATGATAAATATATTCCGTTGGCAGAAAA
AGAATTCTTGAATTACTTGAAAAACAGTGATTCAAACAAGACAAGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164653 WP_002916312.1 NZ_CP057034:793674-793940 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164653 NZ_CP073013:c3062926-3062612 [Marinomonas profundi]
ATGGCTAAGTCGATAAACGAATTACGAAAGAAAATTAAACCAGAGGTTCAAGCAGCGGCTAGAGCTAAAGCTGTTGGCAT
TATTGCTGAAATGACTCTTGCAGAAGTCAGAAAAAAAAGAGGTATCAATCAGGCAGATTTAGCAGGATTTATGAAGATTG
CACAGCCAAATATTTCTCAAATTGAAAATCGTCCAGATGCACTTATTAGTACATTAAATCAATACATTGAAGCTCTGGGA
GGCAAGCTAGAAATACACGCAAAATTCCCTGACGGGCAAGACATAGAAATTTCTCAATTCGCGGCCGTTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References