Detailed information of TA system TA164619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 335905..336893
• Replicon: chromosome
• Accession: NZ_CP056968
• Organism: Escherichia fergusonii strain RHB41-C15

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HV010_RS01575
• Protein ID: WP_014640052.1
• Coordinates: 336507..336893 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: HV010_RS01570
• Protein ID: WP_000458584.1
• Coordinates: 335905..336477 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV010_RS01545	332033..332401	+	369	WP_181588230.1	diacylglycerol kinase	-
HV010_RS01550	332511..333119	+	609	WP_000646099.1	transcriptional repressor LexA	-
HV010_RS01555	333192..334517	+	1326	WP_181588231.1	MATE family efflux transporter DinF	-
HV010_RS01560	334649..334858	+	210	WP_001030605.1	CsbD family protein	-
HV010_RS01565	334909..335424	-	516	WP_181588232.1	zinc uptake transcriptional repressor Zur	-
HV010_RS01570	335905..336477	+	573	WP_000458584.1	SocA family protein	Antitoxin
HV010_RS01575	336507..336893	+	387	WP_014640052.1	hypothetical protein	Toxin
HV010_RS01580	336933..337106	+	174	WP_000390072.1	hypothetical protein	-
HV010_RS01585	337154..337435	-	282	WP_001093917.1	pyocin activator PrtN family protein	-
HV010_RS01590	337472..338044	-	573	WP_001061348.1	3'-5' exoribonuclease	-
HV010_RS01595	338044..338853	-	810	WP_000206745.1	hypothetical protein	-
HV010_RS01600	338853..339215	-	363	WP_001242749.1	phage protein	-
HV010_RS01605	339206..339742	-	537	WP_062858077.1	5'-deoxynucleotidase	-
HV010_RS01610	339870..340694	-	825	WP_001569327.1	DUF2303 family protein	-
HV010_RS01615	340760..341122	-	363	WP_000135680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	332511..387780	55269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T164619 WP_014640052.1 NZ_CP056968:336507-336893 [Escherichia fergusonii]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T164619 NZ_CP073002:355289-355636 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT164619 WP_000458584.1 NZ_CP056968:335905-336477 [Escherichia fergusonii]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT164619 NZ_CP073002:355636-355935 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5