Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4550885..4551470 Replicon chromosome
Accession NZ_CP056967
Organism Citrobacter freundii strain RHB41-C16

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV011_RS21515 Protein ID WP_135912739.1
Coordinates 4550885..4551199 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HV011_RS21520 Protein ID WP_115259723.1
Coordinates 4551192..4551470 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV011_RS21490 4546999..4548579 + 1581 WP_181596015.1 RNA repair transcriptional activator RtcR -
HV011_RS21495 4548684..4548956 + 273 WP_181596016.1 DUF3811 domain-containing protein -
HV011_RS21500 4548953..4549828 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
HV011_RS21505 4550079..4550396 - 318 WP_181540147.1 CcdB family protein -
HV011_RS21510 4550396..4550689 - 294 WP_135912738.1 type II toxin-antitoxin system CcdA family antitoxin -
HV011_RS21515 4550885..4551199 + 315 WP_135912739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV011_RS21520 4551192..4551470 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HV011_RS21525 4551582..4552271 + 690 WP_115259724.1 dipeptidase PepE -
HV011_RS21530 4552400..4554031 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4528681..4551470 22789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11969.88 Da        Isoelectric Point: 9.5570

>T164618 WP_135912739.1 NZ_CP056967:4550885-4551199 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T164618 NZ_CP073002:329318-329686 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT164618 WP_115259723.1 NZ_CP056967:4551192-4551470 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT164618 NZ_CP073002:329100-329321 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References