Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4271334..4271850 Replicon chromosome
Accession NZ_CP056967
Organism Citrobacter freundii strain RHB41-C16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HV011_RS20195 Protein ID WP_181595942.1
Coordinates 4271334..4271618 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HV011_RS20200 Protein ID WP_115259576.1
Coordinates 4271608..4271850 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV011_RS20180 4266535..4268187 + 1653 WP_181595940.1 alpha,alpha-phosphotrehalase -
HV011_RS20185 4268606..4270744 + 2139 WP_115259574.1 anaerobic ribonucleoside-triphosphate reductase -
HV011_RS20190 4270866..4271330 + 465 WP_181595941.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV011_RS20195 4271334..4271618 - 285 WP_181595942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV011_RS20200 4271608..4271850 - 243 WP_115259576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV011_RS20205 4271928..4273841 - 1914 WP_181595943.1 BglG family transcription antiterminator -
HV011_RS20210 4273863..4274603 - 741 WP_181595944.1 KDGP aldolase family protein -
HV011_RS20215 4274600..4275718 - 1119 WP_181595945.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HV011_RS20220 4275702..4276835 - 1134 WP_181595946.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10840.64 Da        Isoelectric Point: 10.0482

>T164616 WP_181595942.1 NZ_CP056967:c4271618-4271334 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAAYHDANKRL

Download         Length: 285 bp

>T164616 NZ_CP072998:123622-123771 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.32 Da        Isoelectric Point: 5.0490

>AT164616 WP_115259576.1 NZ_CP056967:c4271850-4271608 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLDKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT164616 NZ_CP072998:c123577-123518 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References