Detailed information of TA system TA164603

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 855420..856081
• Replicon: chromosome
• Accession: NZ_CP056967
• Organism: Citrobacter freundii strain RHB41-C16

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV011_RS04210
• Protein ID: WP_181596275.1
• Coordinates: 855758..856081 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV011_RS04205
• Protein ID: WP_016239683.1
• Coordinates: 855420..855737 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV011_RS04175	851137..851721	-	585	WP_181596271.1	flavodoxin	-
HV011_RS04180	851731..852492	-	762	WP_016239700.1	carboxymuconolactone decarboxylase family protein	-
HV011_RS04185	852470..852949	-	480	WP_016239699.1	cupin domain-containing protein	-
HV011_RS04190	853014..854471	-	1458	WP_181596272.1	heavy metal sensor histidine kinase	-
HV011_RS04195	854487..855167	-	681	WP_181596273.1	heavy metal response regulator transcription factor	-
HV011_RS04200	855196..855402	+	207	WP_181596274.1	DUF987 family protein	-
HV011_RS04205	855420..855737	+	318	WP_016239683.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV011_RS04210	855758..856081	+	324	WP_181596275.1	TA system toxin CbtA family protein	Toxin
HV011_RS04215	856591..860133	-	3543	Protein_823	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12359.39 Da
• Isoelectric Point: 6.4514

>T164603 WP_181596275.1 NZ_CP056967:855758-856081 [Citrobacter freundii]
MKILPATISQAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGIMNRN

Nucleotide

• Length: 324 bp

>T164603 NZ_CP072996:354089-354436 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11796.42 Da
• Isoelectric Point: 7.2625

>AT164603 WP_016239683.1 NZ_CP056967:855420-855737 [Citrobacter freundii]
MSNTIWGLQRDITPRLGARLVQEGNRLHYLADRASPTGKFSDAESLKLDVAFPHFISKMESMLTTGEMNPRHAHCVTLYY
NGFTCEADTLGCCGYVYVAVYSTQR

Nucleotide

• Length: 318 bp

>AT164603 NZ_CP072996:354436-354735 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA