Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 830516..831216 Replicon chromosome
Accession NZ_CP056967
Organism Citrobacter freundii strain RHB41-C16

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV011_RS04095 Protein ID WP_181596264.1
Coordinates 830893..831216 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV011_RS04090 Protein ID WP_021571970.1
Coordinates 830516..830872 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV011_RS04055 826553..827269 + 717 WP_021571976.1 WYL domain-containing protein -
HV011_RS04060 827305..827757 + 453 WP_021571975.1 hypothetical protein -
HV011_RS04065 827829..828302 + 474 WP_181596262.1 hypothetical protein -
HV011_RS04070 828422..829243 + 822 WP_021571974.1 DUF945 domain-containing protein -
HV011_RS04075 829274..829717 + 444 WP_021571973.1 antirestriction protein -
HV011_RS04080 829730..830272 + 543 WP_181596263.1 DNA repair protein RadC -
HV011_RS04085 830269..830490 + 222 WP_021571971.1 DUF987 family protein -
HV011_RS04090 830516..830872 + 357 WP_021571970.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV011_RS04095 830893..831216 + 324 WP_181596264.1 TA system toxin CbtA family protein Toxin
HV011_RS04100 832567..833121 + 555 WP_181596265.1 recombinase family protein -
HV011_RS04105 833413..834213 + 801 WP_181596266.1 helix-turn-helix domain-containing protein -
HV011_RS04110 834435..834782 + 348 WP_181596267.1 hypothetical protein -
HV011_RS04115 834954..835883 + 930 WP_181596268.1 hypothetical protein -
HV011_RS04120 836007..836126 - 120 Protein_804 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 819444..838202 18758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12404.50 Da        Isoelectric Point: 7.8568

>T164602 WP_181596264.1 NZ_CP056967:830893-831216 [Citrobacter freundii]
MKFLPATNMRAAKPCLPPVTIWQMLLSRLLEQHYGLSLNDTPFCDATVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN

Download         Length: 324 bp

>T164602 NZ_CP072996:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13206.03 Da        Isoelectric Point: 6.7341

>AT164602 WP_021571970.1 NZ_CP056967:830516-830872 [Citrobacter freundii]
MNNHSESGAIPENLPCKQWGLKSTITPCFGARLVQEGYRLHFLADRAGFNGSFSDEHVLRLDQAFPLILKQLELLLTSGE
LSPRHQHCITLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT164602 NZ_CP072996:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References