Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 773748..774402 Replicon chromosome
Accession NZ_CP056967
Organism Citrobacter freundii strain RHB41-C16

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV011_RS03795 Protein ID WP_096755799.1
Coordinates 773995..774402 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV011_RS03790 Protein ID WP_096755798.1
Coordinates 773748..774014 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV011_RS03765 768962..770395 - 1434 WP_181596250.1 6-phospho-beta-glucosidase BglA -
HV011_RS03770 770516..771244 - 729 WP_181596758.1 MurR/RpiR family transcriptional regulator -
HV011_RS03775 771297..771608 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HV011_RS03780 771772..772431 + 660 WP_096755796.1 hemolysin III family protein -
HV011_RS03785 772511..773491 - 981 WP_115257540.1 tRNA-modifying protein YgfZ -
HV011_RS03790 773748..774014 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV011_RS03795 773995..774402 + 408 WP_096755799.1 protein YgfX Toxin
HV011_RS03800 774448..774969 - 522 WP_181596251.1 flavodoxin FldB -
HV011_RS03805 775082..775978 + 897 WP_181596252.1 site-specific tyrosine recombinase XerD -
HV011_RS03810 776002..776715 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV011_RS03815 776721..778454 + 1734 WP_181596253.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T164601 WP_096755799.1 NZ_CP056967:773995-774402 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T164601 NZ_CP072992:31019-31420 [Loktanella salsilacus]
ATGTACATTCTCGACACTAACGTCATCTCGGCCGTGCGCCGCCCGGACCGAGCTCCCAAAGTGGCAGCCTGGTTGCGAGG
CAAGGCTGAGCGGGAACTTTTTCTGAGTGTCATCACGCTGGGCGAAATTGAGCGCGGCATTCGCCAGCAGGAGACTCACG
ACCCTATGTTTGCCATCGATCTTCGCATGTGGCTAGATCGGACGGTCTTGCTATTCTCGGACCGGCTGCTTGCTTTTGAG
GCCGAGGATGCACGCATCTGGGGACGGCTCTCTGCCGAGATTGGCCATAATGGTGCTGATCTGATGATCGCCGCGTCGGC
GCTACGTCATGGCGCTATCGTCGTGACCGGGAATATCAGTGACTTTGCGCCGACTGGTGCTGCGTTGGAGAATCCGTTCT
AG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT164601 WP_096755798.1 NZ_CP056967:773748-774014 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164601 NZ_CP072992:30777-31019 [Loktanella salsilacus]
ATGTGGACTGTTCAGGATGCAAAAAACAAGTTCAGCGCGGTTGTTGACGCAGCACTTGCCGGCACGCCGCAAGAGGTGAC
GCGCCGAGGCAAGCCAGCGGTGGTCGTCCTTTCTTCAGATGAGTACCATCGGCTCCTGAAGGGTGCGGTGAAGGCGCGCG
AGAGCTTTGCAGAACATCTGATGGCATTTCCCGGTGGGGATATCACTCGCGCCTCGGCCGCACCGCGTGATGTAATCTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References