Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3710318..3710972 Replicon chromosome
Accession NZ_CP056961
Organism Escherichia fergusonii strain RHB41-C20

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV012_RS18015 Protein ID WP_181587862.1
Coordinates 3710318..3710725 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HV012_RS18020 Protein ID WP_000354046.1
Coordinates 3710706..3710972 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV012_RS17995 3706275..3708008 - 1734 WP_181587860.1 single-stranded-DNA-specific exonuclease RecJ -
HV012_RS18000 3708014..3708724 - 711 WP_181587861.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV012_RS18005 3708749..3709645 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
HV012_RS18010 3709757..3710278 + 522 WP_001055874.1 flavodoxin FldB -
HV012_RS18015 3710318..3710725 - 408 WP_181587862.1 protein YgfX Toxin
HV012_RS18020 3710706..3710972 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HV012_RS18025 3711224..3712204 + 981 WP_181587863.1 tRNA-modifying protein YgfZ -
HV012_RS18030 3712281..3712940 - 660 WP_000250283.1 hemolysin III family protein -
HV012_RS18035 3713104..3713415 - 312 WP_104917535.1 N(4)-acetylcytidine aminohydrolase -
HV012_RS18040 3713460..3714893 + 1434 WP_181587864.1 6-phospho-beta-glucosidase BglA -
HV012_RS18045 3714941..3715834 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16092.07 Da        Isoelectric Point: 11.2511

>T164586 WP_181587862.1 NZ_CP056961:c3710725-3710318 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLIAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164586 NZ_CP072986:3961194-3961535 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164586 WP_000354046.1 NZ_CP056961:c3710972-3710706 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164586 NZ_CP072986:c3961199-3961123 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References