Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3539116..3539950 Replicon chromosome
Accession NZ_CP056961
Organism Escherichia fergusonii strain RHB41-C20

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag HV012_RS17260 Protein ID WP_039025883.1
Coordinates 3539116..3539493 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag HV012_RS17265 Protein ID WP_039025882.1
Coordinates 3539582..3539950 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV012_RS17225 3534877..3535188 + 312 Protein_3357 hypothetical protein -
HV012_RS17230 3535324..3535425 + 102 WP_000662204.1 hypothetical protein -
HV012_RS17235 3535566..3535831 + 266 Protein_3359 tyrosine-type recombinase/integrase -
HV012_RS17240 3536057..3537376 + 1320 WP_105284452.1 site-specific integrase -
HV012_RS17245 3537469..3538317 - 849 WP_039025884.1 DUF4942 domain-containing protein -
HV012_RS17250 3538414..3538611 - 198 WP_000772024.1 DUF957 domain-containing protein -
HV012_RS17255 3538631..3539119 - 489 Protein_3363 hypothetical protein -
HV012_RS17260 3539116..3539493 - 378 WP_039025883.1 type IV toxin-antitoxin system toxin CbtA Toxin
HV012_RS17265 3539582..3539950 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV012_RS17270 3540000..3540644 - 645 WP_039025881.1 hypothetical protein -
HV012_RS17275 3540659..3540880 - 222 WP_000692312.1 DUF987 domain-containing protein -
HV012_RS17280 3540949..3541425 - 477 WP_001186745.1 RadC family protein -
HV012_RS17285 3541440..3541925 - 486 WP_000214316.1 antirestriction protein -
HV012_RS17290 3542016..3542834 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T164585 WP_039025883.1 NZ_CP056961:c3539493-3539116 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T164585 NZ_CP072986:3653143-3653421 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT164585 WP_039025882.1 NZ_CP056961:c3539950-3539582 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT164585 NZ_CP072986:3652880-3653140 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References