Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3534197..3534995 Replicon chromosome
Accession NZ_CP056951
Organism Escherichia fergusonii strain RHB42-C01

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7MZH4
Locus tag HV015_RS17005 Protein ID WP_001094453.1
Coordinates 3534618..3534995 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7WAC0
Locus tag HV015_RS17000 Protein ID WP_001285601.1
Coordinates 3534197..3534571 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV015_RS16970 3530793..3531248 + 456 WP_000581502.1 hypothetical protein -
HV015_RS16975 3531327..3531560 + 234 WP_001119729.1 DUF905 family protein -
HV015_RS16980 3531660..3532478 + 819 WP_021552432.1 DUF945 domain-containing protein -
HV015_RS16985 3532779..3533252 + 474 WP_046076363.1 antirestriction protein -
HV015_RS16990 3533268..3533744 + 477 WP_021513354.1 RadC family protein -
HV015_RS16995 3533813..3534034 + 222 WP_046076362.1 DUF987 domain-containing protein -
HV015_RS17000 3534197..3534571 + 375 WP_001285601.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV015_RS17005 3534618..3534995 + 378 WP_001094453.1 TA system toxin CbtA family protein Toxin
HV015_RS17010 3534992..3535141 + 150 Protein_3314 hypothetical protein -
HV015_RS17015 3535217..3535414 + 198 WP_023563519.1 DUF957 domain-containing protein -
HV015_RS17020 3535499..3536341 + 843 WP_001529559.1 DUF4942 domain-containing protein -
HV015_RS17025 3536631..3536910 + 280 Protein_3317 DUF4102 domain-containing protein -
HV015_RS17030 3536915..3536995 - 81 Protein_3318 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14181.04 Da        Isoelectric Point: 5.5831

>T164558 WP_001094453.1 NZ_CP056951:3534618-3534995 [Escherichia fergusonii]
MNTLPDTHVRETSGCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T164558 NZ_CP072980:c4156927-4156676 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13653.47 Da        Isoelectric Point: 5.5769

>AT164558 WP_001285601.1 NZ_CP056951:3534197-3534571 [Escherichia fergusonii]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT164558 NZ_CP072980:c4156679-4156425 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References