Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3405116..3405770 Replicon chromosome
Accession NZ_CP056936
Organism Escherichia fergusonii strain RHB42-C13

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HV020_RS16345 Protein ID WP_000244781.1
Coordinates 3405116..3405523 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HV020_RS16350 Protein ID WP_000354046.1
Coordinates 3405504..3405770 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV020_RS16325 3401073..3402806 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HV020_RS16330 3402812..3403522 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV020_RS16335 3403547..3404443 - 897 WP_046076901.1 site-specific tyrosine recombinase XerD -
HV020_RS16340 3404555..3405076 + 522 WP_001055874.1 flavodoxin FldB -
HV020_RS16345 3405116..3405523 - 408 WP_000244781.1 protein YgfX Toxin
HV020_RS16350 3405504..3405770 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HV020_RS16355 3406022..3407002 + 981 WP_046076900.1 tRNA-modifying protein YgfZ -
HV020_RS16360 3407079..3407738 - 660 WP_000250283.1 hemolysin III family protein -
HV020_RS16365 3407902..3408213 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HV020_RS16370 3408258..3409691 + 1434 WP_181575963.1 6-phospho-beta-glucosidase BglA -
HV020_RS16375 3409739..3410632 - 894 WP_181576133.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T164535 WP_000244781.1 NZ_CP056936:c3405523-3405116 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164535 NZ_CP072977:c107085-106936 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164535 WP_000354046.1 NZ_CP056936:c3405770-3405504 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164535 NZ_CP072977:107129-107190 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References