Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3129098..3129717 Replicon chromosome
Accession NZ_CP056936
Organism Escherichia fergusonii strain RHB42-C13

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HV020_RS14990 Protein ID WP_001280991.1
Coordinates 3129499..3129717 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HV020_RS14985 Protein ID WP_104917851.1
Coordinates 3129098..3129472 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV020_RS14975 3124230..3125423 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV020_RS14980 3125446..3128595 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HV020_RS14985 3129098..3129472 + 375 WP_104917851.1 Hha toxicity modulator TomB Antitoxin
HV020_RS14990 3129499..3129717 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HV020_RS14995 3130214..3130684 + 471 WP_002431406.1 YlaC family protein -
HV020_RS15000 3130823..3132373 + 1551 WP_001260376.1 EAL domain-containing protein -
HV020_RS15005 3132415..3132768 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HV020_RS15015 3133147..3133458 + 312 WP_000409911.1 MGMT family protein -
HV020_RS15020 3133489..3134061 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T164534 WP_001280991.1 NZ_CP056936:3129499-3129717 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T164534 NZ_CP072976:4765284-4765391 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.31 Da        Isoelectric Point: 4.8989

>AT164534 WP_104917851.1 NZ_CP056936:3129098-3129472 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164534 NZ_CP072976:c4765231-4765170 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References