Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3534199..3534997 Replicon chromosome
Accession NZ_CP056916
Organism Escherichia fergusonii strain RHB42-C24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7MZH4
Locus tag HV025_RS17005 Protein ID WP_001094453.1
Coordinates 3534620..3534997 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7WAC0
Locus tag HV025_RS17000 Protein ID WP_001285601.1
Coordinates 3534199..3534573 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV025_RS16970 3530795..3531250 + 456 WP_000581502.1 hypothetical protein -
HV025_RS16975 3531329..3531562 + 234 WP_001119729.1 DUF905 family protein -
HV025_RS16980 3531662..3532480 + 819 WP_021552432.1 DUF945 domain-containing protein -
HV025_RS16985 3532781..3533254 + 474 WP_046076363.1 antirestriction protein -
HV025_RS16990 3533270..3533746 + 477 WP_021513354.1 RadC family protein -
HV025_RS16995 3533815..3534036 + 222 WP_046076362.1 DUF987 domain-containing protein -
HV025_RS17000 3534199..3534573 + 375 WP_001285601.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV025_RS17005 3534620..3534997 + 378 WP_001094453.1 TA system toxin CbtA family protein Toxin
HV025_RS17010 3534994..3535143 + 150 Protein_3314 hypothetical protein -
HV025_RS17015 3535219..3535416 + 198 WP_023563519.1 DUF957 domain-containing protein -
HV025_RS17020 3535501..3536343 + 843 WP_001529559.1 DUF4942 domain-containing protein -
HV025_RS17025 3536633..3536912 + 280 Protein_3317 DUF4102 domain-containing protein -
HV025_RS17030 3536917..3536997 - 81 Protein_3318 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14181.04 Da        Isoelectric Point: 5.5831

>T164513 WP_001094453.1 NZ_CP056916:3534620-3534997 [Escherichia fergusonii]
MNTLPDTHVRETSGCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T164513 NZ_CP072970:c4115083-4114742 [Enterobacter sp. BWH 37]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13653.47 Da        Isoelectric Point: 5.5769

>AT164513 WP_001285601.1 NZ_CP056916:3534199-3534573 [Escherichia fergusonii]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT164513 NZ_CP072970:c4115421-4115104 [Enterobacter sp. BWH 37]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References