Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 946257..946911 Replicon chromosome
Accession NZ_CP056910
Organism Citrobacter freundii strain RHBSTW-00006

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV030_RS04700 Protein ID WP_181540418.1
Coordinates 946504..946911 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV030_RS04695 Protein ID WP_096755798.1
Coordinates 946257..946523 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV030_RS04670 941471..942904 - 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -
HV030_RS04675 943025..943753 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV030_RS04680 943806..944117 + 312 WP_181540417.1 N(4)-acetylcytidine aminohydrolase -
HV030_RS04685 944281..944940 + 660 WP_096755796.1 hemolysin III family protein -
HV030_RS04690 945020..946000 - 981 WP_115257540.1 tRNA-modifying protein YgfZ -
HV030_RS04695 946257..946523 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV030_RS04700 946504..946911 + 408 WP_181540418.1 protein YgfX Toxin
HV030_RS04705 946957..947478 - 522 WP_096755800.1 flavodoxin FldB -
HV030_RS04710 947591..948487 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV030_RS04715 948511..949224 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV030_RS04720 949230..950963 + 1734 WP_096755803.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15945.97 Da        Isoelectric Point: 11.2851

>T164478 WP_181540418.1 NZ_CP056910:946504-946911 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPPMQK

Download         Length: 408 bp

>T164478 NZ_CP072949:c4731564-4731232 [Klebsiella pneumoniae MGH 39]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT164478 WP_096755798.1 NZ_CP056910:946257-946523 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164478 NZ_CP072949:c4731902-4731585 [Klebsiella pneumoniae MGH 39]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCGAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References