Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4653315..4654018 Replicon chromosome
Accession NZ_CP056907
Organism Citrobacter freundii strain RHBSTW-00011

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV032_RS22225 Protein ID WP_181634106.1
Coordinates 4653315..4653656 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV032_RS22230 Protein ID WP_063308407.1
Coordinates 4653677..4654018 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV032_RS22205 4649943..4650305 + 363 WP_172862651.1 endoribonuclease SymE -
HV032_RS22210 4650352..4650987 - 636 WP_043018279.1 HNH endonuclease -
HV032_RS22215 4651128..4651868 + 741 WP_181634105.1 HNH endonuclease -
HV032_RS22220 4652049..4653056 - 1008 WP_001757896.1 restriction endonuclease -
HV032_RS22225 4653315..4653656 - 342 WP_181634106.1 TA system toxin CbtA family protein Toxin
HV032_RS22230 4653677..4654018 - 342 WP_063308407.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV032_RS22235 4654029..4654571 - 543 WP_048261921.1 DNA repair protein RadC -
HV032_RS22240 4654584..4655027 - 444 WP_048261923.1 antirestriction protein -
HV032_RS22245 4655058..4655879 - 822 WP_048261925.1 DUF945 domain-containing protein -
HV032_RS22250 4656000..4656473 - 474 WP_032689716.1 hypothetical protein -
HV032_RS22255 4656545..4656997 - 453 WP_052415655.1 hypothetical protein -
HV032_RS22260 4657033..4657749 - 717 WP_032689717.1 WYL domain-containing protein -
HV032_RS22265 4657993..4658868 - 876 WP_048261928.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12740.65 Da        Isoelectric Point: 8.0324

>T164465 WP_181634106.1 NZ_CP056907:c4653656-4653315 [Citrobacter freundii]
MKTLPATTPQAATLCLSSVTVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWEEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T164465 NZ_CP072945:3722413-3722712 [Enterobacter sp. MGH 7]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12722.34 Da        Isoelectric Point: 6.4739

>AT164465 WP_063308407.1 NZ_CP056907:c4654018-4653677 [Citrobacter freundii]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT164465 NZ_CP072945:3722723-3723070 [Enterobacter sp. MGH 7]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References