Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2765631..2766270 Replicon chromosome
Accession NZ_CP056907
Organism Citrobacter freundii strain RHBSTW-00011

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HV032_RS13280 Protein ID WP_043016254.1
Coordinates 2766094..2766270 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV032_RS13275 Protein ID WP_155762299.1
Coordinates 2765631..2766047 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV032_RS13255 2760676..2761620 - 945 WP_043016259.1 ABC transporter permease -
HV032_RS13260 2761621..2762637 - 1017 WP_003833135.1 ABC transporter ATP-binding protein -
HV032_RS13265 2762654..2763799 - 1146 WP_075146199.1 ABC transporter substrate-binding protein -
HV032_RS13270 2764129..2765538 - 1410 WP_075146200.1 PLP-dependent aminotransferase family protein -
HV032_RS13275 2765631..2766047 - 417 WP_155762299.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV032_RS13280 2766094..2766270 - 177 WP_043016254.1 type II toxin-antitoxin system HicA family toxin Toxin
HV032_RS13285 2766534..2767937 + 1404 WP_181633747.1 cytochrome ubiquinol oxidase subunit I -
HV032_RS13290 2767937..2768947 + 1011 WP_043016252.1 cytochrome d ubiquinol oxidase subunit II -
HV032_RS13295 2768947..2769072 + 126 WP_003020230.1 DUF2474 domain-containing protein -
HV032_RS13300 2769262..2769492 + 231 WP_043016251.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.73 Da        Isoelectric Point: 11.2510

>T164461 WP_043016254.1 NZ_CP056907:c2766270-2766094 [Citrobacter freundii]
VKQSEFRRWLESQGVEVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQPGLQ

Download         Length: 177 bp

>T164461 NZ_CP072945:1041030-1041215 [Enterobacter sp. MGH 7]
GTGAAAAGTGCGGATATCATTACTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTTACCGTCCCACATCCTAAAAAGGACATTAAACCAGGCACTCTCGCACAAATCT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15032.29 Da        Isoelectric Point: 4.5468

>AT164461 WP_155762299.1 NZ_CP056907:c2766047-2765631 [Citrobacter freundii]
MRYPVNLVPAVEGGFVVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT164461 NZ_CP072945:1041230-1041637 [Enterobacter sp. MGH 7]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGATGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCACTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAGAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References