164450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4874210..4874826 Replicon chromosome
Accession NZ_CP056899
Organism Citrobacter sp. RHBSTW-00017

Toxin (Protein)


Gene name vapC Uniprot ID A0A2I8SCX0
Locus tag HV037_RS23470 Protein ID WP_049269424.1
Coordinates 4874210..4874584 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R8WIS4
Locus tag HV037_RS23475 Protein ID WP_016155181.1
Coordinates 4874584..4874826 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV037_RS23455 4871713..4872615 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
HV037_RS23460 4872612..4873247 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
HV037_RS23465 4873244..4874173 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
HV037_RS23470 4874210..4874584 - 375 WP_049269424.1 type II toxin-antitoxin system VapC family toxin Toxin
HV037_RS23475 4874584..4874826 - 243 WP_016155181.1 ribbon-helix-helix domain-containing protein Antitoxin
HV037_RS23480 4875032..4875940 + 909 WP_049269423.1 alpha/beta hydrolase -
HV037_RS23485 4876005..4876247 + 243 WP_016155179.1 type II toxin-antitoxin system ParD family antitoxin -
HV037_RS23490 4876240..4876527 + 288 WP_049269420.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV037_RS23495 4876533..4877474 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
HV037_RS23500 4877519..4877956 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV037_RS23505 4877953..4878825 - 873 WP_019077938.1 virulence factor BrkB family protein -
HV037_RS23510 4878819..4879348 - 530 Protein_4598 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13650.78 Da        Isoelectric Point: 8.5373

>T164450 WP_049269424.1 NZ_CP056899:c4874584-4874210 [Citrobacter sp. RHBSTW-00017]
MATGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL

Download         Length: 375 bp

>T164450 NZ_CP072933:c2462858-2462430 [Xylella fastidiosa subsp. multiplex]
ATGATTGTCTTGGATACCAATGTTGTTTCCGAAGCAATGAAACCCGAGCCGGATGCAGCAGTCCGAACCTGGCTCAACGA
GCAGATGAGCGTCACGTTGTACCTATCCAGTGTGACGTTATCTGAACTGTTGTTTGGAATCGCAGTGTTGCCCACAAGTA
AGCGCAAGGACATGTTGGCTCGTACCCTTGATGGCTTGCTTGATCTGTTCAATGAACGGGTGTTGCCGTTCGATACGGAC
GCGGCACGCCACTATGCTGAACTGGCAGTGAAAGCGAGAAACAATGGGCGCGGCTTTCCCACACCGGATGGCTATATCGC
GGCAATTGCTGCATCACGAGGTTACATAGTGGCTTCCCGCGACACCTCAGCCTATGAGTCAAGTGGTGTGCAAGTCATCA
ATCCGTGGCAATACAGCAAACAAACATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.72 Da        Isoelectric Point: 4.3331

>AT164450 WP_016155181.1 NZ_CP056899:c4874826-4874584 [Citrobacter sp. RHBSTW-00017]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW

Download         Length: 243 bp

>AT164450 NZ_CP072933:c2463113-2462859 [Xylella fastidiosa subsp. multiplex]
ATGGCCATGTTGACAGTGCGTAATTTGCCTGATGAAGTCCATCGCGCCTTGCGGGTTCGAGCCGCCACACACGGCCGCAG
TACAGAAGCGGAAGTACGTGAGATTTTAACGAACATAGTCAAGCCGGATGAGCGTGTTCGCATTGGCGATGCCTTGGCTA
TCCTGGGACGCGAGATCGGACTAAATAACGAGGATTTCACGACCTTTGATAAGGTGCGAGACAAGACGCAGGCCGAGCCG
ATGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8SCX0

Antitoxin

Source ID Structure
AlphaFold DB R8WIS4

References