Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4570798..4571551 | Replicon | chromosome |
| Accession | NZ_CP056899 | ||
| Organism | Citrobacter sp. RHBSTW-00017 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | HV037_RS22090 | Protein ID | WP_016154457.1 |
| Coordinates | 4571174..4571551 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HV037_RS22085 | Protein ID | WP_162838704.1 |
| Coordinates | 4570798..4571124 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV037_RS22025 | 4565857..4566123 | + | 267 | WP_032950091.1 | hypothetical protein | - |
| HV037_RS22030 | 4566136..4566447 | + | 312 | WP_009652410.1 | hypothetical protein | - |
| HV037_RS22035 | 4566494..4566964 | + | 471 | WP_009652431.1 | hypothetical protein | - |
| HV037_RS22040 | 4567013..4567525 | + | 513 | WP_032950094.1 | DUF4234 domain-containing protein | - |
| HV037_RS22045 | 4567607..4567828 | + | 222 | WP_032950095.1 | hypothetical protein | - |
| HV037_RS22050 | 4567884..4568117 | + | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| HV037_RS22055 | 4568221..4569039 | + | 819 | WP_009652424.1 | DUF945 domain-containing protein | - |
| HV037_RS22060 | 4569039..4569293 | + | 255 | WP_009652519.1 | hypothetical protein | - |
| HV037_RS22065 | 4569322..4569783 | + | 462 | WP_045890390.1 | antirestriction protein | - |
| HV037_RS22070 | 4569794..4570012 | + | 219 | WP_009652503.1 | hypothetical protein | - |
| HV037_RS22075 | 4570024..4570506 | + | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| HV037_RS22080 | 4570520..4570741 | + | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| HV037_RS22085 | 4570798..4571124 | + | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV037_RS22090 | 4571174..4571551 | + | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| HV037_RS22095 | 4571548..4572039 | + | 492 | WP_009652438.1 | hypothetical protein | - |
| HV037_RS22100 | 4572069..4572272 | + | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| HV037_RS22105 | 4572353..4573198 | + | 846 | Protein_4333 | DUF4942 domain-containing protein | - |
| HV037_RS22110 | 4573210..4573446 | + | 237 | WP_016154458.1 | hypothetical protein | - |
| HV037_RS22115 | 4573850..4574254 | + | 405 | WP_009309932.1 | IS66 family insertion sequence hypothetical protein | - |
| HV037_RS22120 | 4574251..4574601 | + | 351 | WP_009309933.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HV037_RS22125 | 4574632..4576221 | + | 1590 | WP_038423659.1 | IS66 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T164449 WP_016154457.1 NZ_CP056899:4571174-4571551 [Citrobacter sp. RHBSTW-00017]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T164449 NZ_CP072933:1627382-1627669 [Xylella fastidiosa subsp. multiplex]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGTAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGACGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGTAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGACGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT164449 WP_162838704.1 NZ_CP056899:4570798-4571124 [Citrobacter sp. RHBSTW-00017]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT164449 NZ_CP072933:1627147-1627389 [Xylella fastidiosa subsp. multiplex]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTGCTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTGCTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|