164447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4268699..4269275 Replicon chromosome
Accession NZ_CP056899
Organism Citrobacter sp. RHBSTW-00017

Toxin (Protein)


Gene name shpA Uniprot ID A0A2I8S420
Locus tag HV037_RS20595 Protein ID WP_049269953.1
Coordinates 4268988..4269275 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A2I8S1U6
Locus tag HV037_RS20590 Protein ID WP_016155614.1
Coordinates 4268699..4269001 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV037_RS20565 4263969..4264163 + 195 WP_181500139.1 YbdD/YjiX family protein -
HV037_RS20570 4264176..4265132 + 957 WP_049040419.1 GTPase -
HV037_RS20575 4265319..4266893 + 1575 Protein_4032 AAA family ATPase -
HV037_RS20585 4268113..4268391 + 279 Protein_4034 ATP-binding domain-containing protein -
HV037_RS20590 4268699..4269001 - 303 WP_016155614.1 BrnA antitoxin family protein Antitoxin
HV037_RS20595 4268988..4269275 - 288 WP_049269953.1 BrnT family toxin Toxin
HV037_RS20600 4269507..4270673 + 1167 WP_019078303.1 restriction endonuclease -
HV037_RS20605 4270736..4270876 - 141 WP_165500049.1 hypothetical protein -
HV037_RS20610 4270839..4271137 + 299 Protein_4039 type I addiction module toxin, SymE family -
HV037_RS20615 4271268..4271759 - 492 WP_016151575.1 type VI secretion system tube protein Hcp -
HV037_RS20620 4271760..4272266 - 507 WP_047414535.1 hypothetical protein -
HV037_RS20625 4272266..4272628 - 363 WP_181545592.1 DUF2778 domain-containing protein -
HV037_RS20630 4272903..4273967 - 1065 WP_049041982.1 DUF2955 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11433.87 Da        Isoelectric Point: 8.6051

>T164447 WP_049269953.1 NZ_CP056899:c4269275-4268988 [Citrobacter sp. RHBSTW-00017]
MPMEFEWDANKAQSNHRKHGVRFEDAILVFDDPQHLSRQERYENGEYRWQTIGLVHGIVVILVAHSVRFESRFEVIRIIS
ARKADRKERNRYEHS

Download         Length: 288 bp

>T164447 NZ_CP072933:1347150-1347455 [Xylella fastidiosa subsp. multiplex]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAACTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTATCGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11466.12 Da        Isoelectric Point: 10.1293

>AT164447 WP_016155614.1 NZ_CP056899:c4269001-4268699 [Citrobacter sp. RHBSTW-00017]
MSIVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDKQWSEAIRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT164447 NZ_CP072933:1346850-1347146 [Xylella fastidiosa subsp. multiplex]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATATCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S420

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8S1U6

References