Detailed information of TA system TA164435

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1032979..1033751
• Replicon: chromosome
• Accession: NZ_CP056899
• Organism: Citrobacter sp. RHBSTW-00017

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7L6ICB7
• Locus tag: HV037_RS05105
• Protein ID: WP_049238634.1
• Coordinates: 1033362..1033751 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV037_RS05100
• Protein ID: WP_171547612.1
• Coordinates: 1032979..1033305 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV037_RS05070	1029229..1029861	-	633	WP_049238458.1	inovirus Gp2 family protein	-
HV037_RS05075	1030594..1031418	+	825	WP_049238647.1	DUF945 domain-containing protein	-
HV037_RS05080	1031415..1031672	+	258	WP_049238645.1	DUF905 domain-containing protein	-
HV037_RS05085	1031752..1032195	+	444	WP_049238643.1	antirestriction protein	-
HV037_RS05090	1032207..1032686	+	480	WP_049238640.1	DNA repair protein RadC	-
HV037_RS05095	1032700..1032921	+	222	WP_049238638.1	DUF987 domain-containing protein	-
HV037_RS05100	1032979..1033305	+	327	WP_171547612.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV037_RS05105	1033362..1033751	+	390	WP_049238634.1	TA system toxin CbtA family protein	Toxin
HV037_RS05110	1033838..1034677	+	840	WP_049238632.1	DUF4942 domain-containing protein	-
HV037_RS05115	1036092..1036619	+	528	WP_019077624.1	hypothetical protein	-
HV037_RS05120	1036877..1038154	+	1278	WP_016157409.1	Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	tviB / tviC	997613..1039197	41584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (3-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14387.45 Da
• Isoelectric Point: 9.6254

>T164435 WP_049238634.1 NZ_CP056899:1033362-1033751 [Citrobacter sp. RHBSTW-00017]
MQTKLSPLMRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDEQVIQQHIDAGISLSDALNFIVEKYELVRTDRPGF
SIREQSPFITPIDILRARKAAGLMNRGTYKEVTAITRGQHPQANASGKR

Nucleotide

• Length: 390 bp

>T164435 NZ_CP072932:c476058-475804 [Xylella fastidiosa subsp. multiplex]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12174.84 Da
• Isoelectric Point: 6.4673

>AT164435 WP_171547612.1 NZ_CP056899:1032979-1033305 [Citrobacter sp. RHBSTW-00017]
ISEPWWGLRRSVSPCFGARLVQERNSLHYLADRANFDGQFCDADLRYLDQAFPVLMKQLELMLTSGELNPRHQHGVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVTTA

Nucleotide

• Length: 327 bp

>AT164435 NZ_CP072932:c475807-475472 [Xylella fastidiosa subsp. multiplex]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGACAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Structures

Toxin

• AlphaFold DB: A0A7L6ICB7