Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 740634..742257 | Replicon | chromosome |
| Accession | NZ_CP056899 | ||
| Organism | Citrobacter sp. RHBSTW-00017 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A7D6U035 |
| Locus tag | HV037_RS03535 | Protein ID | WP_020833804.1 |
| Coordinates | 740932..742257 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5V9NJV0 |
| Locus tag | HV037_RS03530 | Protein ID | WP_024143021.1 |
| Coordinates | 740634..740927 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV037_RS03510 | 735711..737219 | + | 1509 | WP_001189111.1 | group II intron reverse transcriptase/maturase | - |
| HV037_RS03515 | 737300..737767 | + | 468 | Protein_689 | IS3 family transposase | - |
| HV037_RS03520 | 738343..738840 | + | 498 | WP_103798315.1 | hypothetical protein | - |
| HV037_RS03525 | 738845..740233 | + | 1389 | WP_053271570.1 | hypothetical protein | - |
| HV037_RS03530 | 740634..740927 | + | 294 | WP_024143021.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HV037_RS03535 | 740932..742257 | + | 1326 | WP_020833804.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HV037_RS03540 | 742318..742524 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| HV037_RS03545 | 742626..743036 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| HV037_RS03550 | 743049..743864 | + | 816 | WP_001572439.1 | HNH endonuclease | - |
| HV037_RS03555 | 743947..744726 | + | 780 | Protein_697 | IS5-like element ISKpn26 family transposase | - |
| HV037_RS03560 | 744810..745250 | + | 441 | WP_004189163.1 | IS66 family insertion sequence hypothetical protein | - |
| HV037_RS03565 | 745734..746633 | + | 900 | WP_103798311.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 733450..755088 | 21638 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50307.23 Da Isoelectric Point: 6.0252
>T164432 WP_020833804.1 NZ_CP056899:740932-742257 [Citrobacter sp. RHBSTW-00017]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLDQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLDQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T164432 NZ_CP072914:c5127344-5126982 [Klebsiella oxytoca]
ATGCAAACTACATTGCCCTTCATGCGGGCGGTATCGTCACGTCCGTCTCCCGTTGATGTCTGGCAGACCCTGCTGACCTG
CCTGCTGGAACATCACTATGGTCTCACGCTTAACGATACGCCGTTCAGTGATGAACAGGTAATCCAGCAGCATATCGACG
CAGGTATCTCGCTGTCCGATGCCCTGAATTTTATTGTAGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTCAGC
ATCAGGGAGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGAAAGGCTGCGGGGCTGATGAACCGTGGCAC
GTATAAAGAGGTGACGGCTATTACCAGAGGACAACATCCGTAG
ATGCAAACTACATTGCCCTTCATGCGGGCGGTATCGTCACGTCCGTCTCCCGTTGATGTCTGGCAGACCCTGCTGACCTG
CCTGCTGGAACATCACTATGGTCTCACGCTTAACGATACGCCGTTCAGTGATGAACAGGTAATCCAGCAGCATATCGACG
CAGGTATCTCGCTGTCCGATGCCCTGAATTTTATTGTAGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTCAGC
ATCAGGGAGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGAAAGGCTGCGGGGCTGATGAACCGTGGCAC
GTATAAAGAGGTGACGGCTATTACCAGAGGACAACATCCGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10990.39 Da Isoelectric Point: 9.9492
>AT164432 WP_024143021.1 NZ_CP056899:740634-740927 [Citrobacter sp. RHBSTW-00017]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSVLGVKISFSSATTSSERK
QTEEIYKLNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSVLGVKISFSSATTSSERK
QTEEIYKLNSPARQEDW
Download Length: 294 bp
>AT164432 NZ_CP072914:c5127727-5127401 [Klebsiella oxytoca]
ATCAGCGAACCCTGGTGGGGACTCAGACACAGTGCCTCCCCGTGTTTTGGTGCCCGTCTGGTACAGGAGGGGAACCGCCT
GCACTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGTCTTTCCCTG
TATTGATAAAACAGCTGGAGTTATTGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACGTTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATTCCACTCCTATAGCCAC
GGCATAA
ATCAGCGAACCCTGGTGGGGACTCAGACACAGTGCCTCCCCGTGTTTTGGTGCCCGTCTGGTACAGGAGGGGAACCGCCT
GCACTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGTCTTTCCCTG
TATTGATAAAACAGCTGGAGTTATTGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACGTTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATTCCACTCCTATAGCCAC
GGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D6U035 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5V9NJV0 |