Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4329749..4330503 | Replicon | chromosome |
| Accession | NZ_CP056896 | ||
| Organism | Citrobacter sp. RHBSTW-00021 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | HV039_RS20925 | Protein ID | WP_060659227.1 |
| Coordinates | 4329749..4330126 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HV039_RS20930 | Protein ID | WP_165688905.1 |
| Coordinates | 4330177..4330503 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV039_RS20885 | 4324988..4325743 | - | 756 | WP_046274999.1 | hydroxyacylglutathione hydrolase | - |
| HV039_RS20890 | 4325777..4326499 | + | 723 | WP_019076062.1 | class I SAM-dependent methyltransferase | - |
| HV039_RS20895 | 4326496..4326963 | - | 468 | WP_016151805.1 | ribonuclease HI | - |
| HV039_RS20900 | 4327028..4327756 | + | 729 | WP_029139417.1 | DNA polymerase III subunit epsilon | - |
| HV039_RS20910 | 4328100..4328945 | - | 846 | WP_181631194.1 | DUF4942 domain-containing protein | - |
| HV039_RS20915 | 4329026..4329229 | - | 204 | WP_000413747.1 | DUF957 domain-containing protein | - |
| HV039_RS20920 | 4329261..4329752 | - | 492 | WP_000777682.1 | hypothetical protein | - |
| HV039_RS20925 | 4329749..4330126 | - | 378 | WP_060659227.1 | TA system toxin CbtA family protein | Toxin |
| HV039_RS20930 | 4330177..4330503 | - | 327 | WP_165688905.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV039_RS20935 | 4330560..4330781 | - | 222 | WP_000691981.1 | DUF987 domain-containing protein | - |
| HV039_RS20940 | 4330802..4331281 | - | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| HV039_RS20945 | 4331293..4331763 | - | 471 | WP_000131762.1 | antirestriction protein | - |
| HV039_RS20950 | 4332031..4332849 | - | 819 | WP_001234406.1 | DUF945 domain-containing protein | - |
| HV039_RS20955 | 4332969..4333202 | - | 234 | WP_001114682.1 | DUF905 domain-containing protein | - |
| HV039_RS20960 | 4333279..4333731 | - | 453 | WP_001061894.1 | hypothetical protein | - |
| HV039_RS20965 | 4333791..4334333 | - | 543 | WP_001104018.1 | DUF4339 domain-containing protein | - |
| HV039_RS20970 | 4334396..4334848 | - | 453 | WP_000734138.1 | hypothetical protein | - |
| HV039_RS20975 | 4334845..4335297 | - | 453 | WP_001020418.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4311223..4380127 | 68904 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14152.91 Da Isoelectric Point: 6.9778
>T164428 WP_060659227.1 NZ_CP056896:c4330126-4329749 [Citrobacter sp. RHBSTW-00021]
MQTQPLSSTQEATSRPSPVEIWQQLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQQLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T164428 NZ_CP072914:2009896-2010228 [Klebsiella oxytoca]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCATGAACAAAGCGGAAAACGTCCGGTACTCAT
CGTGTCGAAGGCTTCATTTAACACGTTCACTCGGTTGCCCGTTGTTGTCCCTGTGACCAGCGGCGGAAACTTTGCCCGCG
AAGCCGGTTTTACCGTTTCACTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGCGCCCGGAACGGTAAGCGTCTGGAACGTATACCTGACGCTGTTGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCATGAACAAAGCGGAAAACGTCCGGTACTCAT
CGTGTCGAAGGCTTCATTTAACACGTTCACTCGGTTGCCCGTTGTTGTCCCTGTGACCAGCGGCGGAAACTTTGCCCGCG
AAGCCGGTTTTACCGTTTCACTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGCGCCCGGAACGGTAAGCGTCTGGAACGTATACCTGACGCTGTTGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11889.62 Da Isoelectric Point: 6.9453
>AT164428 WP_165688905.1 NZ_CP056896:c4330503-4330177 [Citrobacter sp. RHBSTW-00021]
ITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELTPRHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
ITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELTPRHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 327 bp
>AT164428 NZ_CP072914:2009638-2009895 [Klebsiella oxytoca]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGC
TCGAAGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATAAGCGAAGAGAGTCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAG
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGC
TCGAAGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATAAGCGAAGAGAGTCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|