Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 177794..178437 Replicon plasmid pRHBSTW-00062_2
Accession NZ_CP056884
Organism Klebsiella pneumoniae strain RHBSTW-00062

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HV049_RS26605 Protein ID WP_014386165.1
Coordinates 178021..178437 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HV049_RS26600 Protein ID WP_032408893.1
Coordinates 177794..178024 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV049_RS26575 172867..173862 - 996 WP_000611945.1 NAD(P)H-quinone oxidoreductase -
HV049_RS26580 173869..175017 - 1149 WP_014386168.1 ABC transporter ATP-binding protein -
HV049_RS26585 175188..176345 - 1158 WP_032408895.1 acetylornithine deacetylase -
HV049_RS26590 176361..177035 - 675 WP_014386166.1 DUF1028 domain-containing protein -
HV049_RS26595 177040..177474 - 435 WP_000103648.1 RidA family protein -
HV049_RS26600 177794..178024 + 231 WP_032408893.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV049_RS26605 178021..178437 + 417 WP_014386165.1 PIN domain-containing protein Toxin
HV049_RS26610 178760..179728 + 969 WP_074422984.1 IS5 family transposase -
HV049_RS26615 179908..180282 - 375 WP_032408891.1 hypothetical protein -
HV049_RS26620 180338..180664 - 327 WP_004152639.1 hypothetical protein -
HV049_RS26625 180661..181389 - 729 WP_014386162.1 plasmid SOS inhibition protein A -
HV049_RS26630 181386..181817 - 432 WP_014386161.1 conjugation system SOS inhibitor PsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(D) / blaSHV-12 - 1..198658 198658
- flank IS/Tn - - 178760..179728 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T164410 WP_014386165.1 NZ_CP056884:178021-178437 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

>T164410 NZ_CP072905:3788168-3788515 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT164410 WP_032408893.1 NZ_CP056884:177794-178024 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp

>AT164410 NZ_CP072905:3788515-3788814 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References