Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 153898..154643 | Replicon | plasmid pRHBSTW-00062_2 |
| Accession | NZ_CP056884 | ||
| Organism | Klebsiella pneumoniae strain RHBSTW-00062 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | HV049_RS26475 | Protein ID | WP_032408901.1 |
| Coordinates | 154152..154643 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | HV049_RS26470 | Protein ID | WP_014386183.1 |
| Coordinates | 153898..154164 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV049_RS26420 | 149451..149864 | - | 414 | WP_013023817.1 | helix-turn-helix domain-containing protein | - |
| HV049_RS26425 | 149865..150143 | - | 279 | WP_004152721.1 | helix-turn-helix domain-containing protein | - |
| HV049_RS26430 | 150133..150452 | - | 320 | Protein_157 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HV049_RS26435 | 150533..150757 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| HV049_RS26440 | 150768..150980 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| HV049_RS26445 | 151042..151368 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| HV049_RS26450 | 152005..152355 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| HV049_RS26455 | 152352..152624 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| HV049_RS26460 | 152814..153299 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| HV049_RS26465 | 153543..153701 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| HV049_RS26470 | 153898..154164 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| HV049_RS26475 | 154152..154643 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| HV049_RS26480 | 155084..155335 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| HV049_RS26485 | 155532..157124 | - | 1593 | Protein_168 | IS66 family transposase | - |
| HV049_RS26490 | 157155..157505 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HV049_RS26495 | 157502..157942 | - | 441 | WP_014386179.1 | IS66 family insertion sequence hypothetical protein | - |
| HV049_RS26500 | 158204..158959 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(D) / blaSHV-12 | - | 1..198658 | 198658 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T164409 WP_032408901.1 NZ_CP056884:154152-154643 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T164409 NZ_CP072905:3762199-3762567 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT164409 WP_014386183.1 NZ_CP056884:153898-154164 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT164409 NZ_CP072905:3761981-3762202 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|