Detailed information of TA system TA164406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4831037..4832718
• Replicon: chromosome
• Accession: NZ_CP056883
• Organism: Klebsiella pneumoniae strain RHBSTW-00062

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486RE08
• Locus tag: HV049_RS23665
• Protein ID: WP_023287018.1
• Coordinates: 4831037..4831954 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486RD25
• Locus tag: HV049_RS23670
• Protein ID: WP_023287017.1
• Coordinates: 4831960..4832718 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV049_RS23645	4826343..4827863	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HV049_RS23650	4827860..4828858	+	999	WP_002885172.1	ribose ABC transporter permease	-
HV049_RS23655	4828889..4829830	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HV049_RS23660	4829905..4830912	+	1008	WP_023287019.1	carbohydrate kinase family protein	-
HV049_RS23665	4831037..4831954	-	918	WP_023287018.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HV049_RS23670	4831960..4832718	-	759	WP_023287017.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HV049_RS23675	4832804..4833532	-	729	WP_004177810.1	response regulator transcription factor	-
HV049_RS23680	4833805..4835952	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HV049_RS23685	4836182..4836868	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34587.04 Da
• Isoelectric Point: 5.7772

>T164406 WP_023287018.1 NZ_CP056883:c4831954-4831037 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T164406 NZ_CP072905:c2857660-2857376 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28534.90 Da
• Isoelectric Point: 10.0870

>AT164406 WP_023287017.1 NZ_CP056883:c4832718-4831960 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT164406 NZ_CP072905:c2857892-2857650 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A486RE08

Antitoxin

• AlphaFold DB: A0A486RD25