Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833351..834008 Replicon chromosome
Accession NZ_CP056883
Organism Klebsiella pneumoniae strain RHBSTW-00062

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV049_RS04245 Protein ID WP_002916310.1
Coordinates 833598..834008 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV049_RS04240 Protein ID WP_002916312.1
Coordinates 833351..833617 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV049_RS04215 828559..829992 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV049_RS04220 830111..830839 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV049_RS04225 830889..831200 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HV049_RS04230 831364..832023 + 660 WP_002916317.1 hemolysin III family protein -
HV049_RS04235 832122..833105 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
HV049_RS04240 833351..833617 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV049_RS04245 833598..834008 + 411 WP_002916310.1 protein YgfX Toxin
HV049_RS04250 834015..834536 - 522 WP_002916308.1 flavodoxin FldB -
HV049_RS04255 834637..835533 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV049_RS04260 835556..836269 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV049_RS04265 836275..838008 + 1734 WP_023286863.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164392 WP_002916310.1 NZ_CP056883:833598-834008 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164392 NZ_CP072904:174763-175086 [Bartonella henselae]
ATGCGTGGATCTCTCGTCACAATAGCGATGCAAGGCGATTTTGGTAAACCAAGACCTGCGTTAATCATTCAAGCCAATCA
ATTTAGTGAACATACAAGCGTGATGGTTTTACCAATTACAAGTACACTTATTGATGCACCATTACTCCGTATTACTGTCC
AACCAGACAGCAAAAATGGTTTACAAAAGCCCTCGCAAGTCATGATTGATAAGATTATGACAGTAAGATGTGAAAAAGTT
AGTCCAGCTTTCGGCTTCATTCATGCAGATAAAATGGTAGAAATTGAACGTTGTTTGGCTGTATTTTTAGGAATAGTAAA
ATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164392 WP_002916312.1 NZ_CP056883:833351-833617 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164392 NZ_CP072904:174539-174763 [Bartonella henselae]
ATGGCTACAATGCACGTCAATGAACGCGTTCAAAAACATCGCAATGCACAAAGAAAAGCAGGTTTGCGTTTAATACAAAT
TTGGGTACCAGATACTCGTCAACCAAACTTTGCAGAAGAGTGTCGACGCCAATGTCGCTTAGTCGCAAAAATGGATAAAA
CAGATACATCTATGCAGTTGTTAATGGATAAATCTTTAATGGATATTGATGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References