Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 18186..18720 Replicon plasmid pRHBSTW-00066_3
Accession NZ_CP056880
Organism Klebsiella pneumoniae strain RHBSTW-00066

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag HV051_RS26820 Protein ID WP_000143805.1
Coordinates 18186..18476 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A387K2U4
Locus tag HV051_RS26825 Protein ID WP_032635065.1
Coordinates 18466..18720 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV051_RS26805 13587..15584 - 1998 WP_032635075.1 choline BCCT transporter BetT -
HV051_RS26810 15874..16470 - 597 WP_032635043.1 recombinase family protein -
HV051_RS26815 17276..17875 + 600 WP_032635044.1 DUF2913 family protein -
HV051_RS26820 18186..18476 - 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV051_RS26825 18466..18720 - 255 WP_032635065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV051_RS26830 18879..19589 - 711 WP_025760373.1 tyrosine-type recombinase/integrase -
HV051_RS26835 19676..20071 - 396 WP_032672763.1 hypothetical protein -
HV051_RS26840 20839..21096 + 258 WP_181575861.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IId / blaSHV-12 / mph(A) - 1..107020 107020
- inside IScluster/Tn - - 15874..22312 6438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T164390 WP_000143805.1 NZ_CP056880:c18476-18186 [Klebsiella pneumoniae]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T164390 NZ_CP072904:c172964-172632 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAACGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9722.07 Da        Isoelectric Point: 4.4356

>AT164390 WP_032635065.1 NZ_CP056880:c18720-18466 [Klebsiella pneumoniae]
MSTIQIRVDDELKKEAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT164390 NZ_CP072904:c172524-172297 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A387K2U4

References