Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 178613..179256 Replicon plasmid pRHBSTW-00066_2
Accession NZ_CP056879
Organism Klebsiella pneumoniae strain RHBSTW-00066

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HV051_RS26610 Protein ID WP_014386165.1
Coordinates 178840..179256 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HV051_RS26605 Protein ID WP_032408893.1
Coordinates 178613..178843 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV051_RS26580 173686..174681 - 996 WP_000611945.1 NAD(P)H-quinone oxidoreductase -
HV051_RS26585 174688..175836 - 1149 WP_014386168.1 ABC transporter ATP-binding protein -
HV051_RS26590 176007..177164 - 1158 WP_032408895.1 acetylornithine deacetylase -
HV051_RS26595 177180..177854 - 675 WP_014386166.1 DUF1028 domain-containing protein -
HV051_RS26600 177859..178293 - 435 WP_000103648.1 RidA family protein -
HV051_RS26605 178613..178843 + 231 WP_032408893.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV051_RS26610 178840..179256 + 417 WP_014386165.1 PIN domain-containing protein Toxin
HV051_RS26615 179579..180547 + 969 WP_074422984.1 IS5 family transposase -
HV051_RS26620 180727..181101 - 375 WP_032408891.1 hypothetical protein -
HV051_RS26625 181157..181483 - 327 WP_004152639.1 hypothetical protein -
HV051_RS26630 181480..182208 - 729 WP_014386162.1 plasmid SOS inhibition protein A -
HV051_RS26635 182205..182636 - 432 WP_014386161.1 conjugation system SOS inhibitor PsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(D) / blaSHV-12 - 1..199477 199477
- flank IS/Tn - - 179579..180547 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T164389 WP_014386165.1 NZ_CP056879:178840-179256 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

>T164389 NZ_CP072904:c172313-172044 [Bartonella henselae]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTCAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGCGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTCCCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGGAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT164389 WP_032408893.1 NZ_CP056879:178613-178843 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp

>AT164389 NZ_CP072904:c172524-172297 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References