Detailed information of TA system TA164385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4832641..4834322
• Replicon: chromosome
• Accession: NZ_CP056878
• Organism: Klebsiella pneumoniae strain RHBSTW-00066

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486RE08
• Locus tag: HV051_RS23670
• Protein ID: WP_023287018.1
• Coordinates: 4832641..4833558 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486RD25
• Locus tag: HV051_RS23675
• Protein ID: WP_023287017.1
• Coordinates: 4833564..4834322 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV051_RS23650	4827947..4829467	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HV051_RS23655	4829464..4830462	+	999	WP_002885172.1	ribose ABC transporter permease	-
HV051_RS23660	4830493..4831434	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HV051_RS23665	4831509..4832516	+	1008	WP_023287019.1	carbohydrate kinase family protein	-
HV051_RS23670	4832641..4833558	-	918	WP_023287018.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HV051_RS23675	4833564..4834322	-	759	WP_023287017.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HV051_RS23680	4834408..4835136	-	729	WP_004177810.1	response regulator transcription factor	-
HV051_RS23685	4835409..4837556	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HV051_RS23690	4837786..4838472	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34587.04 Da
• Isoelectric Point: 5.7772

>T164385 WP_023287018.1 NZ_CP056878:c4833558-4832641 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T164385 NZ_CP072903:c1623605-1623405 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28534.90 Da
• Isoelectric Point: 10.0870

>AT164385 WP_023287017.1 NZ_CP056878:c4834322-4833564 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT164385 NZ_CP072903:c1623408-1623013 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG

Structures

Toxin

• AlphaFold DB: A0A486RE08

Antitoxin

• AlphaFold DB: A0A486RD25