Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1787372..1787962 Replicon chromosome
Accession NZ_CP056878
Organism Klebsiella pneumoniae strain RHBSTW-00066

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HV051_RS08760 Protein ID WP_032421545.1
Coordinates 1787630..1787962 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag HV051_RS08755 Protein ID WP_096106567.1
Coordinates 1787372..1787629 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV051_RS08730 1783207..1783449 - 243 WP_022615591.1 hypothetical protein -
HV051_RS08735 1783716..1785464 + 1749 WP_096106564.1 hypothetical protein -
HV051_RS08740 1785543..1786091 + 549 WP_096106565.1 hypothetical protein -
HV051_RS08745 1786374..1786834 + 461 Protein_1710 hypothetical protein -
HV051_RS08750 1786831..1787037 + 207 WP_096106566.1 helix-turn-helix domain-containing protein -
HV051_RS08755 1787372..1787629 + 258 WP_096106567.1 antitoxin Antitoxin
HV051_RS08760 1787630..1787962 + 333 WP_032421545.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HV051_RS08770 1788284..1789720 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HV051_RS08780 1790086..1791540 - 1455 WP_023286675.1 AMP nucleosidase -
HV051_RS08785 1791670..1791915 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11917.79 Da        Isoelectric Point: 10.0968

>T164372 WP_032421545.1 NZ_CP056878:1787630-1787962 [Klebsiella pneumoniae]
MDRGEIWLVSLDPTSGHEQSGKRPVLIVSKASFNKLTQLPVIVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

>T164372 NZ_CP072902:c262751-262419 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9189.65 Da        Isoelectric Point: 4.7468

>AT164372 WP_096106567.1 NZ_CP056878:1787372-1787629 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLGLSTDSEVGMTIDNGCLVIEPQKRPHYSLEELLAQCDPHAEISEGGREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT164372 NZ_CP072902:c263008-262751 [Bartonella henselae]
ATGCACACAACAAAATTACGTAAAGTTGGAGGGTCTGTTATGCTCTCTATACCGCCGGCATTGCTTGATGTTCTTCATCT
TACTGAGAACACGCAAGTTGGTTTGGCTGTTGATAATGGACAATTGGTTGTGAAGCCACAGACATTTCCAAGTTACACTC
TTGATGAATTGTTAGCTCAATGTAATCCTTCAGATGATTTTGCGGATGAGGATATGGAGTGGTTTGATGCTAAACCTGTT
GGTAGAGAGCTCTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References