Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834831..835488 Replicon chromosome
Accession NZ_CP056878
Organism Klebsiella pneumoniae strain RHBSTW-00066

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV051_RS04250 Protein ID WP_002916310.1
Coordinates 835078..835488 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV051_RS04245 Protein ID WP_002916312.1
Coordinates 834831..835097 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV051_RS04220 830039..831472 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV051_RS04225 831591..832319 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV051_RS04230 832369..832680 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HV051_RS04235 832844..833503 + 660 WP_002916317.1 hemolysin III family protein -
HV051_RS04240 833602..834585 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
HV051_RS04245 834831..835097 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV051_RS04250 835078..835488 + 411 WP_002916310.1 protein YgfX Toxin
HV051_RS04255 835495..836016 - 522 WP_002916308.1 flavodoxin FldB -
HV051_RS04260 836117..837013 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV051_RS04265 837036..837749 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV051_RS04270 837755..839488 + 1734 WP_023286863.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164371 WP_002916310.1 NZ_CP056878:835078-835488 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164371 NZ_CP072902:c262751-262419 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164371 WP_002916312.1 NZ_CP056878:834831-835097 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164371 NZ_CP072902:c262311-262084 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References