Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4558785..4559301 Replicon chromosome
Accession NZ_CP056854
Organism Klebsiella pneumoniae strain RHBSTW-00113

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HV075_RS22280 Protein ID WP_009309309.1
Coordinates 4558785..4559069 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV075_RS22285 Protein ID WP_002886901.1
Coordinates 4559059..4559301 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV075_RS22255 4554269..4554577 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
HV075_RS22260 4554662..4554835 + 174 WP_032412860.1 hypothetical protein -
HV075_RS22265 4554838..4555581 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV075_RS22270 4555938..4558076 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV075_RS22275 4558317..4558781 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV075_RS22280 4558785..4559069 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV075_RS22285 4559059..4559301 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV075_RS22290 4559379..4561289 - 1911 WP_023280782.1 BglG family transcription antiterminator -
HV075_RS22295 4561312..4562466 - 1155 WP_023280781.1 lactonase family protein -
HV075_RS22300 4562533..4563273 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T164363 WP_009309309.1 NZ_CP056854:c4559069-4558785 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T164363 NZ_CP072901:c262752-262420 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT164363 WP_002886901.1 NZ_CP056854:c4559301-4559059 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT164363 NZ_CP072901:c262312-262085 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References