Detailed information of TA system TA164360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2577763..2579351
• Replicon: chromosome
• Accession: NZ_CP056854
• Organism: Klebsiella pneumoniae strain RHBSTW-00113

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV075_RS12680
• Protein ID: WP_023280065.1
• Coordinates: 2577763..2579085 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HV075_RS12685
• Protein ID: WP_002904790.1
• Coordinates: 2579085..2579351 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV075_RS12665	2572820..2575320	+	2501	Protein_2477	fimbrial biogenesis outer membrane usher protein	-
HV075_RS12670	2575308..2576312	+	1005	WP_023280066.1	type 1 fimbrial protein	-
HV075_RS12675	2576454..2577746	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HV075_RS12680	2577763..2579085	-	1323	WP_023280065.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV075_RS12685	2579085..2579351	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV075_RS12690	2579616..2579942	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HV075_RS12695	2579939..2580439	-	501	WP_023280064.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HV075_RS12700	2580417..2581796	-	1380	WP_023280063.1	purine permease	-
HV075_RS12705	2582142..2583296	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HV075_RS12710	2583277..2584200	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49137.45 Da
• Isoelectric Point: 7.5357

>T164360 WP_023280065.1 NZ_CP056854:c2579085-2577763 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPIDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T164360 NZ_CP072900:c715376-715095 [Bartonella henselae]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT164360 WP_002904790.1 NZ_CP056854:c2579351-2579085 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT164360 NZ_CP072900:c715626-715363 [Bartonella henselae]
ATGGCTACCAGTCGCATGGTTCAAGCACGTGTACCGGAAGAAATTCAAAATGTCGCTAGTCAAGTTATTCAAGCTTCAGG
TTTGACAGTGAGTGATGTTGTGAGGGTATTGATGACTCGTATCGCGCAAGATAAAGCTATTCCATCTGTTTTGTTTCAAC
CCAATGCAGAAACCATAGCAGCTTTTGCTGAAGTTGATGAAGGCAACTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTTTATGCGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8