Detailed information of TA system TA164343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2572446..2573085
• Replicon: chromosome
• Accession: NZ_CP056852
• Organism: Citrobacter freundii strain RHBSTW-00119

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8B5QF36
• Locus tag: HV078_RS12455
• Protein ID: WP_003020221.1
• Coordinates: 2572446..2572622 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HV078_RS12460
• Protein ID: WP_127649147.1
• Coordinates: 2572669..2573085 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV078_RS12435	2569224..2569454	-	231	WP_003020233.1	DUF2554 family protein	-
HV078_RS12440	2569644..2569769	-	126	WP_003020230.1	DUF2474 domain-containing protein	-
HV078_RS12445	2569769..2570779	-	1011	WP_003020227.1	cytochrome d ubiquinol oxidase subunit II	-
HV078_RS12450	2570779..2572182	-	1404	WP_003020224.1	cytochrome ubiquinol oxidase subunit I	-
HV078_RS12455	2572446..2572622	+	177	WP_003020221.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV078_RS12460	2572669..2573085	+	417	WP_127649147.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV078_RS12465	2573178..2574587	+	1410	WP_016150280.1	PLP-dependent aminotransferase family protein	-
HV078_RS12470	2574916..2576061	+	1146	WP_003020212.1	ABC transporter substrate-binding protein	-
HV078_RS12475	2576078..2577094	+	1017	WP_003020210.1	ABC transporter ATP-binding protein	-
HV078_RS12480	2577095..2578039	+	945	WP_003843727.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6769.80 Da
• Isoelectric Point: 11.2510

>T164343 WP_003020221.1 NZ_CP056852:2572446-2572622 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Nucleotide

• Length: 177 bp

>T164343 NZ_CP072899:c262791-262459 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15156.38 Da
• Isoelectric Point: 4.5716

>AT164343 WP_127649147.1 NZ_CP056852:2572669-2573085 [Citrobacter freundii]
MRYPVTLTPAVESGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Nucleotide

• Length: 417 bp

>AT164343 NZ_CP072899:c262351-262124 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Structures

Toxin

• AlphaFold DB: A0A8B5QF36