Detailed information of TA system TA164334

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1280594..1281261
• Replicon: chromosome
• Accession: NZ_CP056852
• Organism: Citrobacter freundii strain RHBSTW-00119

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV078_RS06140
• Protein ID: WP_057064441.1
• Coordinates: 1280594..1280923 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV078_RS06145
• Protein ID: WP_007870247.1
• Coordinates: 1280944..1281261 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV078_RS06135	1276327..1279869	-	3543	WP_032949841.1	inverse autotransporter beta domain-containing protein	-
HV078_RS06140	1280594..1280923	-	330	WP_057064441.1	TA system toxin CbtA family protein	Toxin
HV078_RS06145	1280944..1281261	-	318	WP_007870247.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV078_RS06150	1281279..1281500	-	222	WP_001548165.1	DUF987 domain-containing protein	-
HV078_RS06155	1281509..1281985	-	477	WP_057064440.1	RadC family protein	-
HV078_RS06160	1282001..1282480	-	480	WP_081014411.1	antirestriction protein	-
HV078_RS06165	1283334..1285529	-	2196	WP_143113983.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1280594..1319441	38847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12424.59 Da
• Isoelectric Point: 10.1006

>T164334 WP_057064441.1 NZ_CP056852:c1280923-1280594 [Citrobacter freundii]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T164334 NZ_CP072898:c274194-274042 [Bartonella henselae]
GTGCGTGTAATAGATAAGCCCTTAAAAGGACAATTCTCAGGTTTATGGAGATATCGTGTAGGAGATTACAGGATACTTTG
TGAACTCTATGATAAGGAGCTTGTCGTATTAGTTTTGGCTGTTGGACATAGAAAAAATATATATAAAGGTTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11839.44 Da
• Isoelectric Point: 6.9459

>AT164334 WP_007870247.1 NZ_CP056852:c1281261-1280944 [Citrobacter freundii]
MNNTTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT164334 NZ_CP072898:c274521-274294 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAAGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG