Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 977130..977830 Replicon chromosome
Accession NZ_CP056852
Organism Citrobacter freundii strain RHBSTW-00119

Toxin (Protein)


Gene name ypjF Uniprot ID A0A0H3GY64
Locus tag HV078_RS04795 Protein ID WP_014226745.1
Coordinates 977507..977830 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7G2IQI9
Locus tag HV078_RS04790 Protein ID WP_032949996.1
Coordinates 977130..977486 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV078_RS04745 972427..973131 + 705 WP_014226755.1 WYL domain-containing protein -
HV078_RS04750 973131..973700 + 570 WP_032950001.1 hypothetical protein -
HV078_RS04755 973737..974189 + 453 WP_000737933.1 hypothetical protein -
HV078_RS04760 974186..974635 + 450 WP_032949999.1 hypothetical protein -
HV078_RS04765 974707..974937 + 231 WP_014226751.1 DUF905 domain-containing protein -
HV078_RS04770 975036..975857 + 822 WP_014226750.1 DUF945 domain-containing protein -
HV078_RS04775 975888..976331 + 444 WP_014226749.1 antirestriction protein -
HV078_RS04780 976344..976886 + 543 WP_032949998.1 DNA repair protein RadC -
HV078_RS04785 976883..977104 + 222 WP_014226747.1 DUF987 domain-containing protein -
HV078_RS04790 977130..977486 + 357 WP_032949996.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV078_RS04795 977507..977830 + 324 WP_014226745.1 TA system toxin CbtA family protein Toxin
HV078_RS04800 978072..978608 - 537 WP_032949993.1 GNAT family N-acetyltransferase -
HV078_RS04805 979425..981887 + 2463 WP_032949991.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12466.52 Da        Isoelectric Point: 7.1331

>T164333 WP_014226745.1 NZ_CP056852:977507-977830 [Citrobacter freundii]
MKFLPATNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN

Download         Length: 324 bp

>T164333 NZ_CP072897:c1602920-1602720 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13119.92 Da        Isoelectric Point: 6.9376

>AT164333 WP_032949996.1 NZ_CP056852:977130-977486 [Citrobacter freundii]
MNNRSESGAIPENPACQQWGLKRAMTPCFGARLVQEGARLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYITIYPTQR

Download         Length: 357 bp

>AT164333 NZ_CP072897:c1602723-1602328 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCCTTGTCAGAAGGAGCTTTTTTAATA
CAAGTCCCTTTTATTGAAAATGATTCAGAAGTTGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGCTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GY64

Antitoxin

Source ID Structure
AlphaFold DB A0A7G2IQI9

References