Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | ypjF-yeeU/CbtA-CbeA |
Location | 977130..977830 | Replicon | chromosome |
Accession | NZ_CP056852 | ||
Organism | Citrobacter freundii strain RHBSTW-00119 |
Toxin (Protein)
Gene name | ypjF | Uniprot ID | A0A0H3GY64 |
Locus tag | HV078_RS04795 | Protein ID | WP_014226745.1 |
Coordinates | 977507..977830 (+) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A7G2IQI9 |
Locus tag | HV078_RS04790 | Protein ID | WP_032949996.1 |
Coordinates | 977130..977486 (+) | Length | 119 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV078_RS04745 | 972427..973131 | + | 705 | WP_014226755.1 | WYL domain-containing protein | - |
HV078_RS04750 | 973131..973700 | + | 570 | WP_032950001.1 | hypothetical protein | - |
HV078_RS04755 | 973737..974189 | + | 453 | WP_000737933.1 | hypothetical protein | - |
HV078_RS04760 | 974186..974635 | + | 450 | WP_032949999.1 | hypothetical protein | - |
HV078_RS04765 | 974707..974937 | + | 231 | WP_014226751.1 | DUF905 domain-containing protein | - |
HV078_RS04770 | 975036..975857 | + | 822 | WP_014226750.1 | DUF945 domain-containing protein | - |
HV078_RS04775 | 975888..976331 | + | 444 | WP_014226749.1 | antirestriction protein | - |
HV078_RS04780 | 976344..976886 | + | 543 | WP_032949998.1 | DNA repair protein RadC | - |
HV078_RS04785 | 976883..977104 | + | 222 | WP_014226747.1 | DUF987 domain-containing protein | - |
HV078_RS04790 | 977130..977486 | + | 357 | WP_032949996.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HV078_RS04795 | 977507..977830 | + | 324 | WP_014226745.1 | TA system toxin CbtA family protein | Toxin |
HV078_RS04800 | 978072..978608 | - | 537 | WP_032949993.1 | GNAT family N-acetyltransferase | - |
HV078_RS04805 | 979425..981887 | + | 2463 | WP_032949991.1 | poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12466.52 Da Isoelectric Point: 7.1331
>T164333 WP_014226745.1 NZ_CP056852:977507-977830 [Citrobacter freundii]
MKFLPATNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN
MKFLPATNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN
Download Length: 324 bp
>T164333 NZ_CP072897:c1602920-1602720 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 13119.92 Da Isoelectric Point: 6.9376
>AT164333 WP_032949996.1 NZ_CP056852:977130-977486 [Citrobacter freundii]
MNNRSESGAIPENPACQQWGLKRAMTPCFGARLVQEGARLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYITIYPTQR
MNNRSESGAIPENPACQQWGLKRAMTPCFGARLVQEGARLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYITIYPTQR
Download Length: 357 bp
>AT164333 NZ_CP072897:c1602723-1602328 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCCTTGTCAGAAGGAGCTTTTTTAATA
CAAGTCCCTTTTATTGAAAATGATTCAGAAGTTGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGCTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCCTTGTCAGAAGGAGCTTTTTTAATA
CAAGTCCCTTTTATTGAAAATGATTCAGAAGTTGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGCTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY64 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7G2IQI9 |