Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 925531..926185 Replicon chromosome
Accession NZ_CP056852
Organism Citrobacter freundii strain RHBSTW-00119

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV078_RS04520 Protein ID WP_003026936.1
Coordinates 925778..926185 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV078_RS04515 Protein ID WP_003026938.1
Coordinates 925531..925797 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV078_RS04490 920732..922165 - 1434 WP_032950025.1 6-phospho-beta-glucosidase BglA -
HV078_RS04495 922286..923014 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HV078_RS04500 923067..923378 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
HV078_RS04505 923541..924200 + 660 WP_003026947.1 hemolysin III family protein -
HV078_RS04510 924294..925274 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
HV078_RS04515 925531..925797 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HV078_RS04520 925778..926185 + 408 WP_003026936.1 protein YgfX Toxin
HV078_RS04525 926230..926751 - 522 WP_003026933.1 flavodoxin FldB -
HV078_RS04530 926865..927761 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HV078_RS04535 927785..928498 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV078_RS04540 928504..930237 + 1734 WP_032950023.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T164332 WP_003026936.1 NZ_CP056852:925778-926185 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T164332 NZ_CP072897:1596682-1596963 [Bartonella henselae]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT164332 WP_003026938.1 NZ_CP056852:925531-925797 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164332 NZ_CP072897:1596432-1596695 [Bartonella henselae]
ATGGCTACCAGTCGCATGGTTCAAGCACGCGTACCGGAAGAGATTCAAAATGTTGCTAGTCAAGTTATTCAAGCCTCTGG
CTTATCAGTAAGTGATGTTGTGAGAGTATTGATGACACGTATTGCGCAAGATAAAGCTATTCCTCCTTTCTTGTTTCAAC
CCAATGCAGAAACCATAGCGGCTTTTGCCGAACTTGATGAAGGCAATTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTCTATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References