Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 925531..926185 | Replicon | chromosome |
Accession | NZ_CP056852 | ||
Organism | Citrobacter freundii strain RHBSTW-00119 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A0J1NHY7 |
Locus tag | HV078_RS04520 | Protein ID | WP_003026936.1 |
Coordinates | 925778..926185 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | A0A6H3AT26 |
Locus tag | HV078_RS04515 | Protein ID | WP_003026938.1 |
Coordinates | 925531..925797 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV078_RS04490 | 920732..922165 | - | 1434 | WP_032950025.1 | 6-phospho-beta-glucosidase BglA | - |
HV078_RS04495 | 922286..923014 | - | 729 | WP_003838265.1 | MurR/RpiR family transcriptional regulator | - |
HV078_RS04500 | 923067..923378 | + | 312 | WP_003026949.1 | N(4)-acetylcytidine aminohydrolase | - |
HV078_RS04505 | 923541..924200 | + | 660 | WP_003026947.1 | hemolysin III family protein | - |
HV078_RS04510 | 924294..925274 | - | 981 | WP_003026944.1 | tRNA-modifying protein YgfZ | - |
HV078_RS04515 | 925531..925797 | + | 267 | WP_003026938.1 | FAD assembly factor SdhE | Antitoxin |
HV078_RS04520 | 925778..926185 | + | 408 | WP_003026936.1 | protein YgfX | Toxin |
HV078_RS04525 | 926230..926751 | - | 522 | WP_003026933.1 | flavodoxin FldB | - |
HV078_RS04530 | 926865..927761 | + | 897 | WP_003026928.1 | site-specific tyrosine recombinase XerD | - |
HV078_RS04535 | 927785..928498 | + | 714 | WP_003825520.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
HV078_RS04540 | 928504..930237 | + | 1734 | WP_032950023.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15953.89 Da Isoelectric Point: 11.4054
>T164332 WP_003026936.1 NZ_CP056852:925778-926185 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK
Download Length: 408 bp
>T164332 NZ_CP072897:1596682-1596963 [Bartonella henselae]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10558.09 Da Isoelectric Point: 5.1700
>AT164332 WP_003026938.1 NZ_CP056852:925531-925797 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT164332 NZ_CP072897:1596432-1596695 [Bartonella henselae]
ATGGCTACCAGTCGCATGGTTCAAGCACGCGTACCGGAAGAGATTCAAAATGTTGCTAGTCAAGTTATTCAAGCCTCTGG
CTTATCAGTAAGTGATGTTGTGAGAGTATTGATGACACGTATTGCGCAAGATAAAGCTATTCCTCCTTTCTTGTTTCAAC
CCAATGCAGAAACCATAGCGGCTTTTGCCGAACTTGATGAAGGCAATTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTCTATGCGGACGATTGA
ATGGCTACCAGTCGCATGGTTCAAGCACGCGTACCGGAAGAGATTCAAAATGTTGCTAGTCAAGTTATTCAAGCCTCTGG
CTTATCAGTAAGTGATGTTGTGAGAGTATTGATGACACGTATTGCGCAAGATAAAGCTATTCCTCCTTTCTTGTTTCAAC
CCAATGCAGAAACCATAGCGGCTTTTGCCGAACTTGATGAAGGCAATTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTCTATGCGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1NHY7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6H3AT26 |